P98078: Disabled homolog 2
Protein names | - Disabled homolog 2 - Adaptor molecule disabled-2 - Differentially expressed in ovarian carcinoma 2 - DOC-2 - Mitogen-responsive phosphoprotein |
---|---|
Gene names | Dab2 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P98078 |
8
N-termini
6
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSNEVETSTT NGQPDQQAAP KAPSKKEKKK GSEKTDEYLL ARFKGDGVKY KAKLIGIDDV
70 80 90 100 110 120
PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK
130 140 150 160 170 180
ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEDKK
190 200 210 220 230 240
KVEEANKAEE NGSEALMTLD DQANKLKLGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN
250 260 270 280 290 300
SEIDTNQNSL RENPFLTNGV TSCSLPRPKP QASFLPENAF SANLNFFPTP NPDPFRDDPF
310 320 330 340 350 360
AQPDQSAPSS FDSLTSPDQK KASLSSSSTP QSKGPLNGDT DYFGQQFDQL SNRTGKPEAQ
370 380 390 400 410 420
GGPWPYPSSQ TQQAVRTQNG VSEREQNGFH IKSSPNPFVG SPPKGLSVPN GVKQDLESSV
430 440 450 460 470 480
QSSAHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA SEPPGQMSPT GQPAVPQSNF
490 500 510 520 530 540
LDLFKGNAPA PVGPLVGLGT VPVTPPQAGP WTPVVYSPST TVVPGAIISG QPPSFRQPLV
550 560 570 580 590 600
FGTTPAVQVW NQSPSFATPA SPPPPTVWCP TTSVAPNAWS STSPLGNPFQ SNNIFPPPTM
610 620 630 640 650 660
STQSSPQPMM SSVLATPPQP PPRNGPLKDI PSDAFTGLDP LGDKEVKEVK EMFKDFQLRQ
670 680 690 700 710 720
PPLVPSRKGE TPPSGTSSAF SSYFNNKVGI PQEHVDHDDF DANQLLNKIN EPPKPAPRQG
730 740 750 760
VLLGTKSADN SLENPFSKGF SSSNPSVVSQ PASSDPHRSP FGNPFA
Isoforms
- Isoform p93 of Disabled homolog 2 - Isoform p67 of Disabled homolog 2Sequence View
10 20 30 40 50 60
MSNEVETSTT NGQPDQQAAP KAPSKKEKKK GSEKTDEYLL ARFKGDGVKY KAKLIGIDDV
70 80 90 100 110 120
PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK
130 140 150 160 170 180
ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEDKK
190 200 210 220 230 240
KVEEANKAEE NGSEALMTLD DQANKLKLGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN
250 260 270 280 290 300
SEIDTNQNSL RENPFLTNGV TSCSLPRPKP QASFLPENAF SANLNFFPTP NPDPFRDDPF
310 320 330 340 350 360
AQPDQSAPSS FDSLTSPDQK KASLSSSSTP QSKGPLNGDT DYFGQQFDQL SNRTGKPEAQ
370 380 390 400 410 420
GGPWPYPSSQ TQQAVRTQNG VSEREQNGFH IKSSPNPFVG SPPKGLSVPN GVKQDLESSV
430 440 450 460 470 480
QSSAHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA SEPPGQMSPT GQPAVPQSNF
490 500 510 520 530 540
LDLFKGNAPA PVGPLVGLGT VPVTPPQAGP WTPVVYSPST TVVPGAIISG QPPSFRQPLV
550 560 570 580 590 600
FGTTPAVQVW NQSPSFATPA SPPPPTVWCP TTSVAPNAWS STSPLGNPFQ SNNIFPPPTM
610 620 630 640 650 660
STQSSPQPMM SSVLATPPQP PPRNGPLKDI PSDAFTGLDP LGDKEVKEVK EMFKDFQLRQ
670 680 690 700 710 720
PPLVPSRKGE TPPSGTSSAF SSYFNNKVGI PQEHVDHDDF DANQLLNKIN EPPKPAPRQG
730 740 750 760
VLLGTKSADN SLENPFSKGF SSSNPSVVSQ PASSDPHRSP FGNPFA
10 20 30 40 50 60
MSNEVETSTT NGQPDQQAAP KAPSKKEKKK GSEKTDEYLL ARFKGDGVKY KAKLIGIDDV
70 80 90 100 110 120
PDARGDKMSQ DSMMKLKGMA AAGRSQGQHK QRIWVNISLS GIKIIDEKTG VIEHEHPVNK
130 140 150 160 170 180
ISFIARDVTD NRAFGYVCGG EGQHQFFAIK TGQQAEPLVV DLKDLFQVIY NVKKKEEDKK
190 200 210 220 230 240
KVEEANKAEE NGSEALMTLD DQANKLKLGV DQMDLFGDMS TPPDLNSPTE SKDILLVDLN
250 260 270 280 290 300
SEIDTNQNSL RENPFLTNGV TSCSLPRPKP QASFLPENAF SANLNFFPTP NPDPFRDDPF
310 320 330 340 350 360
AQPDQSAPSS FDSLTSPDQK KASLSSSSTP QSKGPLNGDT DYFGQQFDQL SNRTGKPEAQ
370 380 390 400 410 420
GGPWPYPSSQ TQQAVRTQNG VSEREQNGFH IKSSPNPFVG SPPKGLSVPN GVKQDLESSV
430 440 450 460 470 480
QSSAHDSIAI IPPPQSTKPG RGRRTAKSSA NDLLASDIFA SEPPGQMSPT GQPAVPQSNF
490 500 510 520 530 540
LDLFKGNAPA PVGPLVGLGT VPVTPPQAGP WTPVVYSPST TVVPGAIISG QPPSFRQPLV
550 560 570 580 590 600
FGTTPAVQVW NQSPSFATPA SPPPPTVWCP TTSVAPNAWS STSPLGNPFQ SNNIFPPPTM
610 620 630 640 650 660
STQSSPQPMM SSVLATPPQP PPRNGPLKDI PSDAFTGLDP LGDKEVKEVK EMFKDFQLRQ
670 680 690 700 710 720
PPLVPSRKGE TPPSGTSSAF SSYFNNKVGI PQEHVDHDDF DANQLLNKIN EPPKPAPRQG
730 740 750 760
VLLGTKSADN SLENPFSKGF SSSNPSVVSQ PASSDPHRSP FGNPFA
Protein Neighborhood
Domains & Features
8 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P98078-2-unknown | MSNEVE... | 1 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P98078-2-unknown | MSNEVE... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P98078-1-unknown | MSNEVE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72310 | |||
P98078-1-unknown | MSNEVE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72311 | |||
P98078-2-Acetylation | SNEVET... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P98078-2-Acetylation | SNEVET... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110118 | ||
P98078-2-Acetylation | SNEVET... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110119 | ||
P98078-2-Acetylation | SNEVET... | 2 | acetylation- | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | ||
P98078-74-unknown | MKLKGM... | 74 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30371 | |||
P98078-74-unknown | MKLKGM... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140903 | |||
P98078-74-unknown | MKLKGM... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140904 | |||
P98078-77-unknown | KGMAAA... | 77 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P98078-77-unknown | KGMAAA... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196592 | |||
P98078-77-unknown | KGMAAA... | 77 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196593 | |||
P98078-86-unknown | QGQHKQ... | 86 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P98078-86-unknown | QGQHKQ... | 86 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196719 | |||
P98078-86-unknown | QGQHKQ... | 86 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196720 | |||
P98078-236-unknown | LVDLNS... | 236 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30374 | |||
P98078-236-unknown | LVDLNS... | 236 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198358 | |||
P98078-240-unknown | NSEIDT... | 240 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30375 | |||
P98078-240-unknown | NSEIDT... | 240 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt198381 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GIDDVP | 60 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000124145 | |||
...GIDDVP | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt116220 | |||
...GIDDVP | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt116221 | |||
...SQDSMM | 73 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30371 | |||
...SQDSMM | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124045 | |||
...SQDSMM | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124046 | |||
...DEKTGV | 110 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000125696 | |||
...DEKTGV | 110 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt116224 | |||
...DEKTGV | 110 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt116223 | |||
...SKDILL | 235 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30374 | |||
...LLVDLN | 239 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30375 | |||
...GNPFA | 766 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GNPFA | 766 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67929 | |||
...GNPFA | 766 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt67928 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATE_MOUSE | 73 | DSMM.|.MKLK | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> DAB2_MOUSE @73 | ||
CATE_MOUSE | 235 | DILL.|.LVDL | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> DAB2_MOUSE @235 | ||
CATE_MOUSE | 239 | VDLN.|.NSEI | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> DAB2_MOUSE @239 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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