Q00535: Cyclin-dependent-like kinase 5

General Information

Protein names	- Cyclin-dependent-like kinase 5 - 2.7.11.1 - Cell division protein kinase 5 - Serine/threonine-protein kinase PSSALRE - Tau protein kinase II catalytic subunit - TPKII catalytic subunit
Gene names	CDK5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00535

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cyclin-dependent kinase 5 - Isoform 2 of Cyclin-dependent-like kinase 5

Sequence View

        10         20         30         40         50         60
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH
        70         80         90        100        110        120
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR
       130        140        150        160        170        180
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS
       190        200        210        220        230        240
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP
       250        260        270        280        290
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP         10         20         30         40         50         60
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH
        70         80         90        100        110        120
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR
       130        140        150        160        170        180
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS
       190        200        210        220        230        240
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP
       250        260        270        280        290
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00535-1-acetylation	MQKYEK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q00535-1-acetylation	MQKYEK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q00535-1-acetylation	MQKYEK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162496
Q00535-1-unknown	MQKYEK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00535-1-unknown	MQKYEK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70111

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DFCPP	292	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...DFCPP	292	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65729

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)