Q01237: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

General Information

Protein names	- 3-hydroxy-3-methylglutaryl-coenzyme A reductase - HMG-CoA reductase - 1.1.1.34
Gene names	Hmgcr
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01237

2 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS
        70         80         90        100        110        120
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG
       130        140        150        160        170        180
LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG
       190        200        210        220        230        240
VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR
       250        260        270        280        290        300
VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQAKVS LGLDEDVSKR
       310        320        330        340        350        360
IEPSVSLWQF YLSKMISMDI EQVITLSLAF LLAVKYIFFE QAETESTLSL KNPITSPVVT
       370        380        390        400        410        420
SKKAQDNCCR REPLLVRRNQ KLSSVEEDPG ANQERKVEVI KPLVVEAETT SRATFVLGAS
       430        440        450        460        470        480
VASPPSALGT QEPGIELPIE PRPNEECLQI LENAEKGAKF LSDAEIIQLV NAKHIPAYKL
       490        500        510        520        530        540
ETLMETHERG VSIRRQLLST KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA
       550        560        570        580        590        600
GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMTRG PVVRLPRACD
       610        620        630        640        650        660
SAEVKTWLET PEGFAVIKEA FDSTSRFARL QKLHVTMAGR NLYIRFQSRT GDAMGMNMIS
       670        680        690        700        710        720
KGTEKALLKL QEFFPDMQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL
       730        740        750        760        770        780
KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM
       790        800        810        820        830        840
EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI
       850        860        870        880
VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKAA

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01237-1-unknown	MLSRLF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01237-486-unknown	THERGV...	486		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000132155

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGSKYI	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000126959
...GSKYIL	91	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000128294
...FVFMTF	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000132749
...AANIVT	756	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000132155
...TKKAA	887	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)