TopFIND 4.0

Q02108: Guanylate cyclase soluble subunit alpha-1 {ECO:0000305}

General Information

Protein names
- Guanylate cyclase soluble subunit alpha-1 {ECO:0000305}
- GCS-alpha-1
- 4.6.1.2 {ECO:0000269|PubMed:23505436, ECO:0000269|PubMed:24669844, ECO:0000269|PubMed:9742212}
- Guanylate cyclase soluble subunit alpha-3 {ECO:0000303|PubMed:1352257}
- GCS-alpha-3
- Soluble guanylate cyclase large subunit
Gene names GUCY1A3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q02108

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
        70         80         90        100        110        120 
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
       130        140        150        160        170        180 
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
       190        200        210        220        230        240 
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
       250        260        270        280        290        300 
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
       310        320        330        340        350        360 
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
       370        380        390        400        410        420 
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
       430        440        450        460        470        480 
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
       490        500        510        520        530        540 
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
       550        560        570        580        590        600 
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
       610        620        630        640        650        660 
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
       670        680        690    
QQGTNSKPCF QKKDVEDGNA NFLGKASGID 

Isoforms

- Isoform 2 of Guanylate cyclase soluble subunit alpha-3 - Isoform 2 of Guanylate cyclase soluble subunit alpha-1

Sequence View

        10         20         30         40         50         60 
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
        70         80         90        100        110        120 
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
       130        140        150        160        170        180 
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
       190        200        210        220        230        240 
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
       250        260        270        280        290        300 
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
       310        320        330        340        350        360 
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
       370        380        390        400        410        420 
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
       430        440        450        460        470        480 
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
       490        500        510        520        530        540 
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
       550        560        570        580        590        600 
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
       610        620        630        640        650        660 
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
       670        680        690    
QQGTNSKPCF QKKDVEDGNA NFLGKASGID          10         20         30         40         50         60 
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
        70         80         90        100        110        120 
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
       130        140        150        160        170        180 
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
       190        200        210        220        230        240 
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
       250        260        270        280        290        300 
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
       310        320        330        340        350        360 
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
       370        380        390        400        410        420 
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
       430        440        450        460        470        480 
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
       490        500        510        520        530        540 
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
       550        560        570        580        590        600 
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
       610        620        630        640        650        660 
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
       670        680        690    
QQGTNSKPCF QKKDVEDGNA NFLGKASGID 



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q02108-1-unknown MFCTKL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q02108-1-unknown MFCTKL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt75823

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PTTYRL 624 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt71441
    ...ASGID 690 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)