Q02297: Pro-neuregulin-1, membrane-bound isoform

General Information

Protein names	- Pro-neuregulin-1, membrane-bound isoform - Pro-NRG1 - Neuregulin-1 - Acetylcholine receptor-inducing activity - ARIA - Breast cancer cell differentiation factor p45 - Glial growth factor - Heregulin - HRG - Neu differentiation factor - Sensory and motor neuron-derived factor
Gene names	NRG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02297

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pro-neuregulin-1, membrane-bound isoform - Isoform 3 of Pro-neuregulin-1, membrane-bound isoform - Isoform 4 of Pro-neuregulin-1, membrane-bound isoform - Isoform 6 of Pro-neuregulin-1, membrane-bound isoform - Isoform 7 of Pro-neuregulin-1, membrane-bound isoform - Isoform 8 of Pro-neuregulin-1, membrane-bound isoform - Isoform 9 of Pro-neuregulin-1, membrane-bound isoform - Isoform 10 of Pro-neuregulin-1, membrane-bound isoform - Isoform 11 of Pro-neuregulin-1, membrane-bound isoform - Isoform 12 of Pro-neuregulin-1, membrane-bound isoform

Sequence View

        10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV         10         20         30         40         50         60
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS
        70         80         90        100        110        120
SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN
       130        140        150        160        170        180
DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV
       190        200        210        220        230        240
KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ
       250        260        270        280        290        300
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
       310        320        330        340        350        360
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT
       370        380        390        400        410        420
ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE CNSFLRHARE TPDSYRDSPH
       430        440        450        460        470        480
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSMAVSP FMEEERPLLL
       490        500        510        520        530        540
VTPPRLREKK FDHHPQQFSS FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK
       550        560        570        580        590        600
LANSRRAKRT KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83262
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83263
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83264
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83265
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83266
Q02297-1-unknown	MSERKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83267
Q02297-20-unknown	SGKKPE...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112354
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112355
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112356
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112357
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112358
Q02297-20-unknown	SGKKPE...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112359

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELYQKR	241	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ELYQKR	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92070
...DPIAV	640	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DPIAV	640	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78884
...DPIAV	640	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78883
...DPIAV	640	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78880

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)