Q03112: Histone-lysine N-methyltransferase MECOM {ECO:0000305}

General Information

Protein names	- Histone-lysine N-methyltransferase MECOM {ECO:0000305} - 2.1.1.43 {ECO:0000250\|UniProtKB:P14404} - Ecotropic virus integration site 1 protein homolog - EVI-1 - MDS1 and EVI1 complex locus protein {ECO:0000305} - Myelodysplasia syndrome 1 protein - Myelodysplasia syndrome-associated protein 1
Gene names	MECOM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03112

2 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of MDS1 and EVI1 complex locus protein EVI1 - Isoform 4 of MDS1 and EVI1 complex locus protein EVI1 - Isoform 5 of MDS1 and EVI1 complex locus protein EVI1 - Isoform 6 of MDS1 and EVI1 complex locus protein EVI1 - Isoform 1 of Histone-lysine N-methyltransferase MECOM - Isoform 2 of Histone-lysine N-methyltransferase MECOM - Isoform 4 of Histone-lysine N-methyltransferase MECOM - Isoform 5 of Histone-lysine N-methyltransferase MECOM - Isoform 6 of Histone-lysine N-methyltransferase MECOM - Isoform 8 of Histone-lysine N-methyltransferase MECOM - Isoform 9 of Histone-lysine N-methyltransferase MECOM

Sequence View

        10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV         10         20         30         40         50         60
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
        70         80         90        100        110        120
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
       130        140        150        160        170        180
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
       190        200        210        220        230        240
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
       250        260        270        280        290        300
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
       310        320        330        340        350        360
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
       370        380        390        400        410        420
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
       430        440        450        460        470        480
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
       490        500        510        520        530        540
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
       550        560        570        580        590        600
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
       610        620        630        640        650        660
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
       670        680        690        700        710        720
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
       730        740        750        760        770        780
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
       790        800        810        820        830        840
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
       850        860        870        880        890        900
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
       910        920        930        940        950        960
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
       970        980        990       1000       1010       1020
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
      1030       1040       1050       1060       1070       1080
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
      1090       1100       1110       1120       1130       1140
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
      1150       1160       1170       1180       1190       1200
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
      1210       1220       1230
HSTSHSSSNV WHSMARAAAE SSAIQSISHV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q03112-1-unknown	MRSKGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q03112-1-unknown	MRSKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74288
Q03112-1-unknown	MRSKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74289
Q03112-1-unknown	MRSKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97752
Q03112-1-unknown	MRSKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97753
Q03112-1-unknown	MRSKGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74286
Q03112-26-unknown	LEEMPD...	26	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417506
Q03112-26-unknown	LEEMPD...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195416
Q03112-26-unknown	LEEMPD...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195417
Q03112-26-unknown	LEEMPD...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195418
Q03112-26-unknown	LEEMPD...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195419

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VYGNYP	21	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418689
...VYGNYP	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153677
...VYGNYP	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153678
...VYGNYP	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153679
...VYGNYP	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153680
...IPLEEM	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418046
...IPLEEM	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153744
...IPLEEM	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153745
...IPLEEM	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153746
...IPLEEM	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153747
...PYKAPI	67	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418828
...PYKAPI	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154007
...PYKAPI	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154008
...PYKAPI	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154009
...KIEVGE	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417922
...KIEVGE	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419757
...KIEVGE	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420072
...KIEVGE	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154416
...KIEVGE	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154417
...KIEVGE	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154418
...SYGWEI	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417299
...SYGWEI	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154676
...SYGWEI	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154677
...SYGWEI	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154678
...ASIAEK	670	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417506
...MNGSHF	1051	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MNGSHF	1051	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69906
...MNGSHF	1051	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69907
...MNGSHF	1051	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69905
...MNGSHF	1051	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69904

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)