TopFIND 4.0

Q05084: Islet cell autoantigen 1

General Information

Protein names
- Islet cell autoantigen 1
- 69 kDa islet cell autoantigen
- ICA69
- Islet cell autoantigen p69
- ICAp69
- p69
Gene names ICA1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q05084

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL 
        70         80         90        100        110        120 
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL 
       130        140        150        160        170        180 
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL 
       190        200        210        220        230        240 
DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH 
       250        260        270        280        290        300 
FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS 
       310        320        330        340        350        360 
QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA 
       370        380        390        400        410        420 
GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ 
       430        440        450        460        470        480 
TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL 
   
LNA

Isoforms

- Isoform 2 of Islet cell autoantigen 1 - Isoform 3 of Islet cell autoantigen 1

Sequence View

        10         20         30         40         50         60 
MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL 
        70         80         90        100        110        120 
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL 
       130        140        150        160        170        180 
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL 
       190        200        210        220        230        240 
DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH 
       250        260        270        280        290        300 
FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS 
       310        320        330        340        350        360 
QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA 
       370        380        390        400        410        420 
GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ 
       430        440        450        460        470        480 
TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL 
   
LNA         10         20         30         40         50         60 
MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL 
        70         80         90        100        110        120 
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL 
       130        140        150        160        170        180 
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL 
       190        200        210        220        230        240 
DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH 
       250        260        270        280        290        300 
FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS 
       310        320        330        340        350        360 
QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA 
       370        380        390        400        410        420 
GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ 
       430        440        450        460        470        480 
TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL 
   
LNA



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q05084-1-unknown MSGHKC... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q05084-1-unknown MSGHKC... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77466
    Q05084-294- AAVQEP... 294 Subtiligase Based Positive Selection Wells apoptotic_MM1s_bort 23264352

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ELLNA 483 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...ELLNA 483 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt73084

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)