Q05209: Tyrosine-protein phosphatase non-receptor type 12

General Information

Protein names	- Tyrosine-protein phosphatase non-receptor type 12 - 3.1.3.48 {ECO:0000269\|PubMed:27134172, ECO:0000269\|PubMed:8454633} - PTP-PEST {ECO:0000303\|PubMed:8454633} - Protein-tyrosine phosphatase G1 - PTPG1
Gene names	PTPN12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05209

6 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tyrosine-protein phosphatase non-receptor type 12 - Isoform 3 of Tyrosine-protein phosphatase non-receptor type 12

Sequence View

        10         20         30         40         50         60
MEQVEILRKF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK
        70         80         90        100        110        120
KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM
       130        140        150        160        170        180
IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCEDEQAR TDYFIRTLLL
       190        200        210        220        230        240
EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA
       250        260        270        280        290        300
ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
       310        320        330        340        350        360
YEIHGAQKIA DGVNEINTEN MVSSIEPEKQ DSPPPKPPRT RSCLVEGDAK EEILQPPEPH
       370        380        390        400        410        420
PVPPILTPSP PSAFPTVTTV WQDNDRYHPK PVLHMVSSEQ HSADLNRNYS KSTELPGKNE
       430        440        450        460        470        480
STIEQIDKKL ERNLSFEIKK VPLQEGPKSF DGNTLLNRGH AIKIKSASPC IADKISKPQE
       490        500        510        520        530        540
LSSDLNVGDT SQNSCVDCSV TQSNKVSVTP PEESQNSDTP PRPDRLPLDE KGHVTWSFHG
       550        560        570        580        590        600
PENAIPIPDL SEGNSSDINY QTRKTVSLTP SPTTQVETPD LVDHDNTSPL FRTPLSFTNP
       610        620        630        640        650        660
LHSDDSDSDE RNSDGAVTQN KTNISTASAT VSAATSTESI STRKVLPMSI ARHNIAGTTH
       670        680        690        700        710        720
SGAEKDVDVS EDSPPPLPER TPESFVLASE HNTPVRSEWS ELQSQERSEQ KKSEGLITSE
       730        740        750        760        770        780
NEKCDHPAGG IHYEMCIECP PTFSDKREQI SENPTEATDI GFGNRCGKPK GPRDPPSEWT

        10         20         30         40         50         60
MEQVEILRKF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK
        70         80         90        100        110        120
KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM
       130        140        150        160        170        180
IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCEDEQAR TDYFIRTLLL
       190        200        210        220        230        240
EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA
       250        260        270        280        290        300
ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
       310        320        330        340        350        360
YEIHGAQKIA DGVNEINTEN MVSSIEPEKQ DSPPPKPPRT RSCLVEGDAK EEILQPPEPH
       370        380        390        400        410        420
PVPPILTPSP PSAFPTVTTV WQDNDRYHPK PVLHMVSSEQ HSADLNRNYS KSTELPGKNE
       430        440        450        460        470        480
STIEQIDKKL ERNLSFEIKK VPLQEGPKSF DGNTLLNRGH AIKIKSASPC IADKISKPQE
       490        500        510        520        530        540
LSSDLNVGDT SQNSCVDCSV TQSNKVSVTP PEESQNSDTP PRPDRLPLDE KGHVTWSFHG
       550        560        570        580        590        600
PENAIPIPDL SEGNSSDINY QTRKTVSLTP SPTTQVETPD LVDHDNTSPL FRTPLSFTNP
       610        620        630        640        650        660
LHSDDSDSDE RNSDGAVTQN KTNISTASAT VSAATSTESI STRKVLPMSI ARHNIAGTTH
       670        680        690        700        710        720
SGAEKDVDVS EDSPPPLPER TPESFVLASE HNTPVRSEWS ELQSQERSEQ KKSEGLITSE
       730        740        750        760        770        780
NEKCDHPAGG IHYEMCIECP PTFSDKREQI SENPTEATDI GFGNRCGKPK GPRDPPSEWT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q05209-1-Acetylation	MEQVEI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q05209-1-Acetylation	MEQVEI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q05209-1-Acetylation	MEQVEI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q05209-120-unknown	MIWEYN...	120		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86492
Q05209-120-unknown	MIWEYN...	120		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404050
Q05209-120-unknown	MIWEYN...	120		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392429
Q05209-120-unknown	MIWEYN...	120		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392526
Q05209-131-unknown	MACREF...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86491
Q05209-131-unknown	MACREF...	131		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397991
Q05209-131-unknown	MACREF...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108113
Q05209-493-unknown	NSCVDC...	493		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385079
Q05209-493-unknown	NSCVDC...	493		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199695
Q05209-493-unknown	NSCVDC...	493		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199694
Q05209-507-unknown	SVTPPE...	507		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176107
Q05209-507-unknown	SVTPPE...	507		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176106
Q05209-507-	SVTPPE...	507			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FKISCE	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404050
...FKISCE	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155180
...FKISCE	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155179
...DVPSSF	205	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392526
...DVPSSF	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155695
...DVPSSF	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155694
...TQRHSA	275	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430726
...EQISEN	752	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385079
...PSEWT	780	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSEWT	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82109
...PSEWT	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82110

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)