Q05512: Serine/threonine-protein kinase MARK2

General Information

Protein names	- Serine/threonine-protein kinase MARK2 - 2.7.11.1 - 2.7.11.26 - ELKL motif kinase 1 - EMK-1 - MAP/microtubule affinity-regulating kinase 2 - PAR1 homolog - PAR1 homolog b - Par-1b - mPar-1b
Gene names	Mark2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05512

5 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase MARK2 - Isoform 3 of Serine/threonine-protein kinase MARK2 - Isoform 4 of Serine/threonine-protein kinase MARK2

Sequence View

        10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMLRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKIDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRSSD QAVPAIPTSN
       430        440        450        460        470        480
SYSKKTQSNN AENKRPEEET GRKASSTAKV PASPLPGLDR KKTTPAPSTN SVLSTSTNRS
       490        500        510        520        530        540
RNSPLLDRAS LGQASIQNGK DSLTMPGSRA STASASAAVS AARPRQHQKS MSASVHPNKA
       550        560        570        580        590        600
SGLPPTESNC EVPRPSTAPQ RVPVASPSAH NISSSSGAPD RTNFPRGVSS RSTFHAGQLR
       610        620        630        640        650        660
QVRDQQNLPY GVTPASPSGH SQGRRGASGS IFSKFTSKFV RRNLNEPESK DRVETLRPHV
       670        680        690        700        710        720
VGSGGTDKDK EEFREAKPRS LRFTWSMKTT SSMEPNEMMR EIRKVLDANS CQSELHERYM
       730        740        750        760        770
LLCVHGTPGH ENFVQWEMEV CKLPRLSLNG VRFKRISGTS MAFKNIASKI ANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMLRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKIDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRSSD QAVPAIPTSN
       430        440        450        460        470        480
SYSKKTQSNN AENKRPEEET GRKASSTAKV PASPLPGLDR KKTTPAPSTN SVLSTSTNRS
       490        500        510        520        530        540
RNSPLLDRAS LGQASIQNGK DSLTMPGSRA STASASAAVS AARPRQHQKS MSASVHPNKA
       550        560        570        580        590        600
SGLPPTESNC EVPRPSTAPQ RVPVASPSAH NISSSSGAPD RTNFPRGVSS RSTFHAGQLR
       610        620        630        640        650        660
QVRDQQNLPY GVTPASPSGH SQGRRGASGS IFSKFTSKFV RRNLNEPESK DRVETLRPHV
       670        680        690        700        710        720
VGSGGTDKDK EEFREAKPRS LRFTWSMKTT SSMEPNEMMR EIRKVLDANS CQSELHERYM
       730        740        750        760        770
LLCVHGTPGH ENFVQWEMEV CKLPRLSLNG VRFKRISGTS MAFKNIASKI ANELKL         10         20         30         40         50         60
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMLRGRNS ATSADEQPHI GNYRLLKTIG
        70         80         90        100        110        120
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE
       130        140        150        160        170        180
TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN
       190        200        210        220        230        240
LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKIDGPE VDVWSLGVIL
       250        260        270        280        290        300
YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
       310        320        330        340        350        360
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL
       370        380        390        400        410        420
LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRSSD QAVPAIPTSN
       430        440        450        460        470        480
SYSKKTQSNN AENKRPEEET GRKASSTAKV PASPLPGLDR KKTTPAPSTN SVLSTSTNRS
       490        500        510        520        530        540
RNSPLLDRAS LGQASIQNGK DSLTMPGSRA STASASAAVS AARPRQHQKS MSASVHPNKA
       550        560        570        580        590        600
SGLPPTESNC EVPRPSTAPQ RVPVASPSAH NISSSSGAPD RTNFPRGVSS RSTFHAGQLR
       610        620        630        640        650        660
QVRDQQNLPY GVTPASPSGH SQGRRGASGS IFSKFTSKFV RRNLNEPESK DRVETLRPHV
       670        680        690        700        710        720
VGSGGTDKDK EEFREAKPRS LRFTWSMKTT SSMEPNEMMR EIRKVLDANS CQSELHERYM
       730        740        750        760        770
LLCVHGTPGH ENFVQWEMEV CKLPRLSLNG VRFKRISGTS MAFKNIASKI ANELKL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q05512-1-unknown	MSSART...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q05512-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80440
Q05512-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80441
Q05512-1-unknown	MSSART...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80442
Q05512-34-unknown	MLRGRN...	34	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000025921
Q05512-34-unknown	MLRGRN...	34	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129894
Q05512-34-unknown	MLRGRN...	34	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000131266
Q05512-34-unknown	MLRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133113
Q05512-34-unknown	MLRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133114
Q05512-34-unknown	MLRGRN...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133115
Q05512-385-unknown	NSSAPS...	385	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129490
Q05512-385-unknown	NSSAPS...	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133125
Q05512-385-unknown	NSSAPS...	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133126
Q05512-385-unknown	NSSAPS...	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133127
Q05512-459-unknown	DRKKTT...	459	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000132482
Q05512-459-unknown	DRKKTT...	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133121
Q05512-459-unknown	DRKKTT...	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133122
Q05512-459-unknown	DRKKTT...	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133123
Q05512-464-unknown	TPAPST...	464	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000128549
Q05512-464-unknown	TPAPST...	464	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133117
Q05512-464-unknown	TPAPST...	464	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133118
Q05512-464-unknown	TPAPST...	464	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133119

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YRLLKT	57	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000131266
...YRLLKT	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115748
...YRLLKT	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115749
...YRLLKT	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115750
...DKTQLN	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129924
...DKTQLN	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115744
...DKTQLN	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115745
...DKTQLN	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115746
...VLNHPN	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000128779
...VLNHPN	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115740
...VLNHPN	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115741
...VLNHPN	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115742
...KFVRRN	642	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129490
...KFVRRN	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115737
...KFVRRN	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115738
...KFVRRN	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115736
...NSCQSE	713	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000132482
...NSCQSE	713	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115733
...NSCQSE	713	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115734
...NSCQSE	713	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115732
...NELKL	776	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NELKL	776	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76059
...NELKL	776	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76060
...NELKL	776	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76058

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)