Q06265: Exosome complex component RRP45

General Information

Protein names	- Exosome complex component RRP45 - Autoantigen PM/Scl 1 - Exosome component 9 - P75 polymyositis-scleroderma overlap syndrome-associated autoantigen - Polymyositis/scleroderma autoantigen 1 - Polymyositis/scleroderma autoantigen 75 kDa - PM/Scl-75
Gene names	EXOSC9
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06265

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Exosome complex component RRP45 - Isoform 3 of Exosome complex component RRP45 - Isoform 4 of Exosome complex component RRP45

Sequence View

        10         20         30         40         50         60
MKETPLSNCE RRFLLRAIEE KKRLDGRQTY DYRNIRISFG TDYGCCIVEL GKTRVLGQVS
        70         80         90        100        110        120
CELVSPKLNR ATEGILFFNL ELSQMAAPAF EPGRQSDLLV KLNRLMERCL RNSKCIDTES
       130        140        150        160        170        180
LCVVAGEKVW QIRVDLHLLN HDGNIIDAAS IAAIVALCHF RRPDVSVQGD EVTLYTPEER
       190        200        210        220        230        240
DPVPLSIHHM PICVSFAFFQ QGTYLLVDPN EREERVMDGL LVIAMNKHRE ICTIQSSGGI
       250        260        270        280        290        300
MLLKDQVLRC SKIAGVKVAE ITELILKALE NDQKVRKEGG KFGFAESIAN QRITAFKMEK
       310        320        330        340        350        360
APIDTSDVEE KAEEIIAEAE PPSEVVSTPV LWTPGTAQIG EGVENSWGDL EDSEKEDDEG
       370        380        390        400        410        420
GGDQAIILDG IKMDTGVEVS DIGSQDAPII LSDSEEEEMI ILEPDKNPKK IRTQTTSAKQ
       430
EKAPSKKPVK RRKKKRAAN         10         20         30         40         50         60
MKETPLSNCE RRFLLRAIEE KKRLDGRQTY DYRNIRISFG TDYGCCIVEL GKTRVLGQVS
        70         80         90        100        110        120
CELVSPKLNR ATEGILFFNL ELSQMAAPAF EPGRQSDLLV KLNRLMERCL RNSKCIDTES
       130        140        150        160        170        180
LCVVAGEKVW QIRVDLHLLN HDGNIIDAAS IAAIVALCHF RRPDVSVQGD EVTLYTPEER
       190        200        210        220        230        240
DPVPLSIHHM PICVSFAFFQ QGTYLLVDPN EREERVMDGL LVIAMNKHRE ICTIQSSGGI
       250        260        270        280        290        300
MLLKDQVLRC SKIAGVKVAE ITELILKALE NDQKVRKEGG KFGFAESIAN QRITAFKMEK
       310        320        330        340        350        360
APIDTSDVEE KAEEIIAEAE PPSEVVSTPV LWTPGTAQIG EGVENSWGDL EDSEKEDDEG
       370        380        390        400        410        420
GGDQAIILDG IKMDTGVEVS DIGSQDAPII LSDSEEEEMI ILEPDKNPKK IRTQTTSAKQ
       430
EKAPSKKPVK RRKKKRAAN         10         20         30         40         50         60
MKETPLSNCE RRFLLRAIEE KKRLDGRQTY DYRNIRISFG TDYGCCIVEL GKTRVLGQVS
        70         80         90        100        110        120
CELVSPKLNR ATEGILFFNL ELSQMAAPAF EPGRQSDLLV KLNRLMERCL RNSKCIDTES
       130        140        150        160        170        180
LCVVAGEKVW QIRVDLHLLN HDGNIIDAAS IAAIVALCHF RRPDVSVQGD EVTLYTPEER
       190        200        210        220        230        240
DPVPLSIHHM PICVSFAFFQ QGTYLLVDPN EREERVMDGL LVIAMNKHRE ICTIQSSGGI
       250        260        270        280        290        300
MLLKDQVLRC SKIAGVKVAE ITELILKALE NDQKVRKEGG KFGFAESIAN QRITAFKMEK
       310        320        330        340        350        360
APIDTSDVEE KAEEIIAEAE PPSEVVSTPV LWTPGTAQIG EGVENSWGDL EDSEKEDDEG
       370        380        390        400        410        420
GGDQAIILDG IKMDTGVEVS DIGSQDAPII LSDSEEEEMI ILEPDKNPKK IRTQTTSAKQ
       430
EKAPSKKPVK RRKKKRAAN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06265-1-unknown	MKETPL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06265-1-unknown	MKETPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74329
Q06265-1-unknown	MKETPL...	1		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q06265-1-unknown	MKETPL...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q06265-1-unknown	MKETPL...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q06265-85-unknown	MAAPAF...	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74330
Q06265-85-unknown	MAAPAF...	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74331
Q06265-85-unknown	MAAPAF...	85	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100996

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRAAN	439	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRAAN	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69948
...KRAAN	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69949
...KRAAN	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69947

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)