Q06787: Synaptic functional regulator FMR1 {ECO:0000305}

General Information

Protein names	- Synaptic functional regulator FMR1 {ECO:0000305} - Fragile X mental retardation protein 1 {ECO:0000312\|HGNC:HGNC:3775} - FMRP {ECO:0000303\|PubMed:9659908} - Protein FMR-1 {ECO:0000303\|PubMed:1710175}
Gene names	FMR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06787

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Fragile X mental retardation protein 1 - Isoform 2 of Fragile X mental retardation protein 1 - Isoform 3 of Fragile X mental retardation protein 1 - Isoform 4 of Fragile X mental retardation protein 1 - Isoform 5 of Fragile X mental retardation protein 1 - Isoform 7 of Fragile X mental retardation protein 1 - Isoform 8 of Fragile X mental retardation protein 1 - Isoform 1 of Synaptic functional regulator FMR1 - Isoform 2 of Synaptic functional regulator FMR1 - Isoform 3 of Synaptic functional regulator FMR1 - Isoform 4 of Synaptic functional regulator FMR1 - Isoform 5 of Synaptic functional regulator FMR1 - Isoform 7 of Synaptic functional regulator FMR1 - Isoform 8 of Synaptic functional regulator FMR1 - Isoform 9 of Synaptic functional regulator FMR1 - Isoform 10 of Synaptic functional regulator FMR1 - Isoform 11 of Synaptic functional regulator FMR1

Sequence View

        10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP         10         20         30         40         50         60
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPDR QIPFHDVRFP PPVGYNKDIN
        70         80         90        100        110        120
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
       130        140        150        160        170        180
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR
       190        200        210        220        230        240
AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN
       250        260        270        280        290        300
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
       310        320        330        340        350        360
GKLIQEIVDK SGVVRVRIEA ENEKNVPQEE EIMPPNSLPS NNSRVGPNAP EEKKHLDIKE
       370        380        390        400        410        420
NSTHFSQPNS TKVQRVLVAS SVVAGESQKP ELKAWQGMVP FVFVGTKDSI ANATVLLDYH
       430        440        450        460        470        480
LNYLKEVDQL RLERLQIDEQ LRQIGASSRP PPNRTDKEKS YVTDDGQGMG RGSRPYRNRG
       490        500        510        520        530        540
HGRRGPGYTS GTNSEASNAS ETESDHRDEL SDWSLAPTEE ERESFLRRGD GRRRGGGGRG
       550        560        570        580        590        600
QGGRGRGGGF KGNDDHSRTD NRPRNPREAK GRTTDGSLQI RVDCNNERSV HTKTLQNTSS
       610        620        630
EGSRLRTGKD RNQKKEKPDS VDGQQPLVNG VP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06787-1-Acetylation	MEELVV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q06787-1-Acetylation	MEELVV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98816
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98817
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98818
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98819
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98820
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98814
Q06787-1-Acetylation	MEELVV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98815
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75305
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75306
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75307
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75308
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75309
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75310
Q06787-1-unknown	MEELVV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75311

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VNGVP	632	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70929
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70927
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70923
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70925
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70926
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70928
...VNGVP	632	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70924

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)