Q07864: DNA polymerase epsilon catalytic subunit A

General Information

Protein names	- DNA polymerase epsilon catalytic subunit A - 2.7.7.7 - DNA polymerase II subunit A
Gene names	POLE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07864

7 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLRSGGRRR ADPGADGEAS RDDGATSSVS ALKRLERSQW TDKMDLRFGF ERLKEPGEKT
        70         80         90        100        110        120
GWLINMHPTE ILDEDKRLGS AVDYYFIQDD GSRFKVALPY KPYFYIATRK GCEREVSSFL
       130        140        150        160        170        180
SKKFQGKIAK VETVPKEDLD LPNHLVGLKR NYIRLSFHTV EDLVKVRKEI SPAVKKNREQ
       190        200        210        220        230        240
DHASDAYTAL LSSVLQRGGV ITDEEETSKK IADQLDNIVD MREYDVPYHI RLSIDLKIHV
       250        260        270        280        290        300
AHWYNVRYRG NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI
       310        320        330        340        350        360
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE AHLIQRWFEH VQETKPTIMV
       370        380        390        400        410        420
TYNGDFFDWP FVEARAAVHG LSMQQEIGFQ KDSQGEYKAP QCIHMDCLRW VKRDSYLPVG
       430        440        450        460        470        480
SHNLKAAAKA KLGYDPVELD PEDMCRMATE QPQTLATYSV SDAVATYYLY MKYVHPFIFA
       490        500        510        520        530        540
LCTIIPMEPD EVLRKGSGTL CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHVLDSETYV
       550        560        570        580        590        600
GGHVEALESG VFRSDIPCRF RMNPAAFDFL LQRVEKTLRH ALEEEEKVPV EQVTNFEEVC
       610        620        630        640        650        660
DEIKSKLASL KDVPSRIECP LIYHLDVGAM YPNIILTNRL QPSAMVDEAT CAACDFNKPG
       670        680        690        700        710        720
ANCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP EGPARAFHEL SREEQAKYEK
       730        740        750        760        770        780
RRLADYCRKA YKKIHITKVE ERLTTICQRE NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS
       790        800        810        820        830        840
AAVEVGDAAE VKRCKNMEVL YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA
       850        860        870        880        890        900
NIITQARELI EQIGRPLELD TDGIWCVLPN SFPENFVFKT TNVKKPKVTI SYPGAMLNIM
       910        920        930        940        950        960
VKEGFTNDQY QELAEPSSLT YVTRSENSIF FEVDGPYLAM ILPASKEEGK KLKKRYAVFN
       970        980        990       1000       1010       1020
EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE EVYGSVAKVA DYWLDVLYSK
      1030       1040       1050       1060       1070       1080
AANMPDSELF ELISENRSMS RKLEDYGEQK STSISTAKRL AEFLGDQMVK DAGLSCRYII
      1090       1100       1110       1120       1130       1140
SRKPEGSPVT ERAIPLAIFQ AEPTVRKHFL RKWLKSSSLQ DFDIRAILDW DYYIERLGSA
      1150       1160       1170       1180       1190       1200
IQKIITIPAA LQQVKNPVPR VKHPDWLHKK LLEKNDVYKQ KKISELFTLE GRRQVTMAEA
      1210       1220       1230       1240       1250       1260
SEDSPRPSAP DMEDFGLVKL PHPAAPVTVK RKRVLWESQE ESQDLTPTVP WQEILGQPPA
      1270       1280       1290       1300       1310       1320
LGTSQEEWLV WLRFHKKKWQ LQARQRLARR KRQRLESAEG VLRPGAIRDG PATGLGSFLR
      1330       1340       1350       1360       1370       1380
RTARSILDLP WQIVQISETS QAGLFRLWAL VGSDLHCIRL SIPRVFYVNQ RVAKAEEGAS
      1390       1400       1410       1420       1430       1440
YRKVNRVLPR SNMVYNLYEY SVPEDMYQEH INEINAELSA PDIEGVYETQ VPLLFRALVH
      1450       1460       1470       1480       1490       1500
LGCVCVVNKQ LVRHLSGWEA ETFALEHLEM RSLAQFSYLE PGSIRHIYLY HHAQAHKALF
      1510       1520       1530       1540       1550       1560
GIFIPSQRRA SVFVLDTVRS NQMPSLGALY SAEHGLLLEK VGPELLPPPK HTFEVRAETD
      1570       1580       1590       1600       1610       1620
LKTICRAIQR FLLAYKEERR GPTLIAVQSS WELKRLASEI PVLEEFPLVP ICVADKINYG
      1630       1640       1650       1660       1670       1680
VLDWQRHGAR RMIRHYLNLD TCLSQAFEMS RYFHIPIGNL PEDISTFGSD LFFARHLQRH
      1690       1700       1710       1720       1730       1740
NHLLWLSPTA RPDLGGKEAD DNCLVMEFDD QATVEINSSG CYSTVCVELD LQNLAVNTIL
      1750       1760       1770       1780       1790       1800
QSHHVNDMEG ADSMGISFDV IQQASLEDMI TGGQAASAPA SYDETALCSN TFRILKSMVV
      1810       1820       1830       1840       1850       1860
GWVKEITQYH NIYADNQVMH FYRWLRSPSS LLHDPALHRT LHNMMKKLFL QLIAEFKRLG
      1870       1880       1890       1900       1910       1920
SSVIYANFNR IILCTKKRRV EDAIAYVEYI TSSIHSKETF HSLTISFSRC WEFLLWMDPS
      1930       1940       1950       1960       1970       1980
NYGGIKGKVS SRIHCGLQDS QKAGGAEDEQ ENEDDEEERD GEEEEEAEES NVEDLLENNW
      1990       2000       2010       2020       2030       2040
NILQFLPQAA SCQNYFLMIV SAYIVAVYHC MKDGLRRSAP GSTPVRRRGA SQLSQEAEGA
      2050       2060       2070       2080       2090       2100
VGALPGMITF SQDYVANELT QSFFTITQKI QKKVTGSRNS TELSEMFPVL PGSHLLLNNP
      2110       2120       2130       2140       2150       2160
ALEFIKYVCK VLSLDTNITN QVNKLNRDLL RLVDVGEFSE EAQFRDPCRS YVLPEVICRS
      2170       2180       2190       2200       2210       2220
CNFCRDLDLC KDSSFSEDGA VLPQWLCSNC QAPYDSSAIE MTLVEVLQKK LMAFTLQDLV
      2230       2240       2250       2260       2270       2280
CLKCRGVKET SMPVYCSCAG DFALTIHTQV FMEQIGIFRN IAQHYGMSYL LETLEWLLQK

NPQLGH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q07864-1-unknown	MSLRSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07864-217-unknown	NIVDMR...	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2103
Q07864-221-unknown	MREYDV...	221	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442519
Q07864-383-unknown	MQQEIG...	383	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443213
Q07864-1024-unknown	MPDSEL...	1024	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439052
Q07864-1197-unknown	MAEASE...	1197	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439842
Q07864-1215-unknown	FGLVKL...	1215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2104

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADQLDN	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2103
...CRFRMN	562	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443213
...PDMEDF	1214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2104
...LGSFLR	1319	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439842
...ILDLPW	1330	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439052
...ASYRKV	1383	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442519
...PQLGH	2286	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	216	QLDN.\|.NIVD	inferred from experiment	unknown	MEROPS	Linn S	Liu W et al.:Proteolysis of the human DNA po... (C14.003)	11058115,
CASP3_HUMAN	1214	MEDF.\|.FGLV	inferred from experiment	unknown	MEROPS	Linn S	Liu W et al.:Proteolysis of the human DNA po... (C14.003)	11058115,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)