Q07973: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

General Information

Protein names	- 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial - 24-OHase - Vitamin D(3) 24-hydroxylase - 1.14.15.16 {ECO:0000269\|PubMed:15574355} - Cytochrome P450 24A1 - Cytochrome P450-CC24
Gene names	CYP24A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07973

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG
        70         80         90        100        110        120
PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
       130        140        150        160        170        180
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN
       190        200        210        220        230        240
EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
       250        260        270        280        290        300
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
       310        320        330        340        350        360
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL
       370        380        390        400        410        420
PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ
       430        440        450        460        470        480
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV
       490        500        510
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR

Isoforms

- Isoform 2 of 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial - Isoform 3 of 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Sequence View

        10         20         30         40         50         60
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG
        70         80         90        100        110        120
PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
       130        140        150        160        170        180
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN
       190        200        210        220        230        240
EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
       250        260        270        280        290        300
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
       310        320        330        340        350        360
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL
       370        380        390        400        410        420
PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ
       430        440        450        460        470        480
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV
       490        500        510
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR         10         20         30         40         50         60
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG
        70         80         90        100        110        120
PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
       130        140        150        160        170        180
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN
       190        200        210        220        230        240
EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
       250        260        270        280        290        300
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
       310        320        330        340        350        360
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL
       370        380        390        400        410        420
PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ
       430        440        450        460        470        480
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV
       490        500        510
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q07973-1-unknown	MSSPIS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71509
Q07973-36-unknown	PQPREV...	36	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07973-36-unknown	PQPREV...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115261
Q07973-36-unknown	PQPREV...	36	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AFCQR	514	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AFCQR	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67128
...AFCQR	514	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67127

TopFIND

Q07973: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates