TopFIND 4.0

Q08048: Hepatocyte growth factor

General Information

Protein names
- Hepatocyte growth factor
- Hepatopoietin-A
- Scatter factor
- SF
- Hepatocyte growth factor alpha chain
- Hepatocyte growth factor beta chain
Gene names Hgf
Organism Mus musculus
Protease Family
Protease ID S01.982
Chromosome location
UniProt ID Q08048

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI 
        70         80         90        100        110        120 
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
       130        140        150        160        170        180 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
       190        200        210        220        230        240 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
       250        260        270        280        290        300 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP 
       310        320        330        340        350        360 
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
       370        380        390        400        410        420 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
       430        440        450        460        470        480 
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN 
       490        500        510        520        530        540 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR 
       550        560        570        580        590        600 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
       610        620        630        640        650        660 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
       670        680        690        700        710        720 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH 
   
KVILTYKL

Isoforms

- Isoform Short of Hepatocyte growth factor - Isoform NK1 of Hepatocyte growth factor

Sequence View

        10         20         30         40         50         60 
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI 
        70         80         90        100        110        120 
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
       130        140        150        160        170        180 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
       190        200        210        220        230        240 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
       250        260        270        280        290        300 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP 
       310        320        330        340        350        360 
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
       370        380        390        400        410        420 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
       430        440        450        460        470        480 
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN 
       490        500        510        520        530        540 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR 
       550        560        570        580        590        600 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
       610        620        630        640        650        660 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
       670        680        690        700        710        720 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH 
   
KVILTYKL         10         20         30         40         50         60 
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI 
        70         80         90        100        110        120 
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY 
       130        140        150        160        170        180 
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN 
       190        200        210        220        230        240 
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT 
       250        260        270        280        290        300 
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP 
       310        320        330        340        350        360 
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG 
       370        380        390        400        410        420 
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM 
       430        440        450        460        470        480 
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN 
       490        500        510        520        530        540 
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR 
       550        560        570        580        590        600 
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 
       610        620        630        640        650        660 
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL 
       670        680        690        700        710        720 
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH 
   
KVILTYKL



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)