TopFIND 4.0

Q08351: Thrombopoietin receptor

General Information

Protein names
- Thrombopoietin receptor
- TPO-R
- Myeloproliferative leukemia protein
- Proto-oncogene c-Mpl
- CD110
Gene names Mpl
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q08351

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSWALFMVT SCLLLALPNQ AQVTSQDVFL LALGTEPLNC FSQTFEDLTC FWDEEEAAPS 
        70         80         90        100        110        120 
GTYQLLYAYR GEKPRACPLY SQSVPTFGTR YVCQFPAQDE VRLFFPLHLW VKNVSLNQTL 
       130        140        150        160        170        180 
IQRVLFVDSV GLPAPPRVIK ARGGSQPGEL QIHWEAPAPE ISDFLRHELR YGPTDSSNAT 
       190        200        210        220        230        240 
APSVIQLLST ETCCPTLWMP NPVPVLDQPP CVHPTASQPH GPAPFLTVKG GSCLVSGLQA 
       250        260        270        280        290        300 
GKSYWLQLRS QPDGVSLRGS WGPWSFPVTV DLPGDAVTIG LQCFTLDLKM VTCQWQQQDR 
       310        320        330        340        350        360 
TSSQGFFRHS RTRCCPTDRD PTWEKCEEEE PRPGSQPALV SRCHFKSRND SVIHILVEVT 
       370        380        390        400        410        420 
TAQGAVHSYL GSPFWIHQAV LLPTPSLHWR EVSSGRLELE WQHQSSWAAQ ETCYQLRYTG 
       430        440        450        460        470        480 
EGREDWKVLE PSLGARGGTL ELRPRARYSL QLRARLNGPT YQGPWSAWSP PARVSTGSET 
       490        500        510        520        530        540 
AWITLVTALL LVLSLSALLG LLLLKWQFPA HYRRLRHALW PSLPDLHRVL GQYLRDTAAL 
       550        560        570        580        590        600 
SPSKATVTDS CEEVEPSLLE ILPKSSESTP LPLCPSQPQM DYRGLQPCLR TMPLSVCPPM 
       610        620    
AETGSCCTTH IANHSYLPLS YWQQP

Isoforms

- Isoform Mpl-tr of Thrombopoietin receptor

Sequence View

        10         20         30         40         50         60 
MPSWALFMVT SCLLLALPNQ AQVTSQDVFL LALGTEPLNC FSQTFEDLTC FWDEEEAAPS 
        70         80         90        100        110        120 
GTYQLLYAYR GEKPRACPLY SQSVPTFGTR YVCQFPAQDE VRLFFPLHLW VKNVSLNQTL 
       130        140        150        160        170        180 
IQRVLFVDSV GLPAPPRVIK ARGGSQPGEL QIHWEAPAPE ISDFLRHELR YGPTDSSNAT 
       190        200        210        220        230        240 
APSVIQLLST ETCCPTLWMP NPVPVLDQPP CVHPTASQPH GPAPFLTVKG GSCLVSGLQA 
       250        260        270        280        290        300 
GKSYWLQLRS QPDGVSLRGS WGPWSFPVTV DLPGDAVTIG LQCFTLDLKM VTCQWQQQDR 
       310        320        330        340        350        360 
TSSQGFFRHS RTRCCPTDRD PTWEKCEEEE PRPGSQPALV SRCHFKSRND SVIHILVEVT 
       370        380        390        400        410        420 
TAQGAVHSYL GSPFWIHQAV LLPTPSLHWR EVSSGRLELE WQHQSSWAAQ ETCYQLRYTG 
       430        440        450        460        470        480 
EGREDWKVLE PSLGARGGTL ELRPRARYSL QLRARLNGPT YQGPWSAWSP PARVSTGSET 
       490        500        510        520        530        540 
AWITLVTALL LVLSLSALLG LLLLKWQFPA HYRRLRHALW PSLPDLHRVL GQYLRDTAAL 
       550        560        570        580        590        600 
SPSKATVTDS CEEVEPSLLE ILPKSSESTP LPLCPSQPQM DYRGLQPCLR TMPLSVCPPM 
       610        620    
AETGSCCTTH IANHSYLPLS YWQQP



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YWQQP 625 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)