TopFIND 4.0

Q08477: Docosahexaenoic acid omega-hydroxylase CYP4F3 {ECO:0000305}

General Information

Protein names
- Docosahexaenoic acid omega-hydroxylase CYP4F3 {ECO:0000305}
- 1.14.14.79 {ECO:0000269|PubMed:16820285}
- 20-hydroxyeicosatetraenoic acid synthase {ECO:0000303|PubMed:11461919}
- 20-HETE synthase {ECO:0000303|PubMed:11461919}
- 1.14.14.- {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:16820285}
- CYPIVF3
- Cytochrome P450 4F3
- Cytochrome P450-LTB-omega
- Leukotriene-B(4) 20-monooxygenase 2
- Leukotriene-B(4) omega-hydroxylase 2
- 1.14.14.94 {ECO:0000269|PubMed:8486631}
Gene names CYP4F3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q08477

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 
        70         80         90        100        110        120 
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 
       130        140        150        160        170        180 
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
       190        200        210        220        230        240 
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 
       250        260        270        280        290        300 
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
       310        320        330        340        350        360 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
       370        380        390        400        410        420 
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 
       430        440        450        460        470        480 
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 
       490        500        510        520    
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS 

Isoforms

- Isoform CYP4F3B of Leukotriene-B(4) omega-hydroxylase 2 - Isoform CYP4F3B of Cytochrome P450 4F3

Sequence View

        10         20         30         40         50         60 
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 
        70         80         90        100        110        120 
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 
       130        140        150        160        170        180 
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
       190        200        210        220        230        240 
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 
       250        260        270        280        290        300 
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
       310        320        330        340        350        360 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
       370        380        390        400        410        420 
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 
       430        440        450        460        470        480 
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 
       490        500        510        520    
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS          10         20         30         40         50         60 
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 
        70         80         90        100        110        120 
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 
       130        140        150        160        170        180 
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
       190        200        210        220        230        240 
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 
       250        260        270        280        290        300 
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
       310        320        330        340        350        360 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
       370        380        390        400        410        420 
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 
       430        440        450        460        470        480 
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 
       490        500        510        520    
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS 



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q08477-1-unknown MPQLSL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q08477-1-unknown MPQLSL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt71532

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VEPLS 520 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VEPLS 520 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt67150

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)