Q08AE8: Protein spire homolog 1

General Information

Protein names	- Protein spire homolog 1 - Spir-1
Gene names	SPIRE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q08AE8

5 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 5 of Protein spire homolog 1 - Isoform 2 of Protein spire homolog 1 - Isoform 3 of Protein spire homolog 1 - Isoform 4 of Protein spire homolog 1

Sequence View

        10         20         30         40         50         60
MAQAAGPAGG GEPRTEAVGG EGPREPGAAG GAAGGSRDAL SLEEILRLYN QPINEEQAWA
        70         80         90        100        110        120
VCYQCCGSLR AAARRRQPRH RVRSAAQIRV WRDGAVTLAP AADDAGEPPP VAGKLGYSQC
       130        140        150        160        170        180
METEVIESLG IIIYKALDYG LKENEERELS PPLEQLIDHM ANTVEADGSN DEGYEAAEEG
       190        200        210        220        230        240
LGDEDEKRKI SAIRSYRDVM KLCAAHLPTE SDAPNHYQAV CRALFAETME LHTFLTKIKS
       250        260        270        280        290        300
AKENLKKIQE MEKSDESSTD LEELKNADWA RFWVQVMRDL RNGVKLKKVQ ERQYNPLPIE
       310        320        330        340        350        360
YQLTPYEMLM DDIRCKRYTL RKVMVNGDIP PRLKKSAHEI ILDFIRSRPP LNPVSARKLK
       370        380        390        400        410        420
PTPPRPRSLH ERILEEIKAE RKLRPVSPEE IRRSRLAMRP LSMSYSFDLS DVTTPESTKN
       430        440        450        460        470        480
LVESSMVNGG LTSQTKENGL STSQQVPAQR KKLLRAPTLA ELDSSESEEE TLHKSTSSSS
       490        500        510        520        530        540
VSPSFPEEPV LEAVSTRKKP PKFLPISSTP QPERRQPPQR RHSIEKETPT NVRQFLPPSR
       550        560        570        580        590        600
QSSRSLEEFC YPVECLALTV EEVMHIRQVL VKAELEKYQQ YKDIYTALKK GKLCFCCRTR
       610        620        630        640        650        660
RFSFFTWSYT CQFCKRPVCS QCCKKMRLPS KPYSTLPIFS LGPSALQRGE SSMRSEKPST
       670        680        690        700        710        720
AHHRPLRSIA RFSSKSKSMD KSDEELQFPK ELMEDWSTME VCVDCKKFIS EIISSSRRSL
       730        740        750
VLANKRARLK RKTQSFYMSS PGPSEYCPSE RTISEI         10         20         30         40         50         60
MAQAAGPAGG GEPRTEAVGG EGPREPGAAG GAAGGSRDAL SLEEILRLYN QPINEEQAWA
        70         80         90        100        110        120
VCYQCCGSLR AAARRRQPRH RVRSAAQIRV WRDGAVTLAP AADDAGEPPP VAGKLGYSQC
       130        140        150        160        170        180
METEVIESLG IIIYKALDYG LKENEERELS PPLEQLIDHM ANTVEADGSN DEGYEAAEEG
       190        200        210        220        230        240
LGDEDEKRKI SAIRSYRDVM KLCAAHLPTE SDAPNHYQAV CRALFAETME LHTFLTKIKS
       250        260        270        280        290        300
AKENLKKIQE MEKSDESSTD LEELKNADWA RFWVQVMRDL RNGVKLKKVQ ERQYNPLPIE
       310        320        330        340        350        360
YQLTPYEMLM DDIRCKRYTL RKVMVNGDIP PRLKKSAHEI ILDFIRSRPP LNPVSARKLK
       370        380        390        400        410        420
PTPPRPRSLH ERILEEIKAE RKLRPVSPEE IRRSRLAMRP LSMSYSFDLS DVTTPESTKN
       430        440        450        460        470        480
LVESSMVNGG LTSQTKENGL STSQQVPAQR KKLLRAPTLA ELDSSESEEE TLHKSTSSSS
       490        500        510        520        530        540
VSPSFPEEPV LEAVSTRKKP PKFLPISSTP QPERRQPPQR RHSIEKETPT NVRQFLPPSR
       550        560        570        580        590        600
QSSRSLEEFC YPVECLALTV EEVMHIRQVL VKAELEKYQQ YKDIYTALKK GKLCFCCRTR
       610        620        630        640        650        660
RFSFFTWSYT CQFCKRPVCS QCCKKMRLPS KPYSTLPIFS LGPSALQRGE SSMRSEKPST
       670        680        690        700        710        720
AHHRPLRSIA RFSSKSKSMD KSDEELQFPK ELMEDWSTME VCVDCKKFIS EIISSSRRSL
       730        740        750
VLANKRARLK RKTQSFYMSS PGPSEYCPSE RTISEI         10         20         30         40         50         60
MAQAAGPAGG GEPRTEAVGG EGPREPGAAG GAAGGSRDAL SLEEILRLYN QPINEEQAWA
        70         80         90        100        110        120
VCYQCCGSLR AAARRRQPRH RVRSAAQIRV WRDGAVTLAP AADDAGEPPP VAGKLGYSQC
       130        140        150        160        170        180
METEVIESLG IIIYKALDYG LKENEERELS PPLEQLIDHM ANTVEADGSN DEGYEAAEEG
       190        200        210        220        230        240
LGDEDEKRKI SAIRSYRDVM KLCAAHLPTE SDAPNHYQAV CRALFAETME LHTFLTKIKS
       250        260        270        280        290        300
AKENLKKIQE MEKSDESSTD LEELKNADWA RFWVQVMRDL RNGVKLKKVQ ERQYNPLPIE
       310        320        330        340        350        360
YQLTPYEMLM DDIRCKRYTL RKVMVNGDIP PRLKKSAHEI ILDFIRSRPP LNPVSARKLK
       370        380        390        400        410        420
PTPPRPRSLH ERILEEIKAE RKLRPVSPEE IRRSRLAMRP LSMSYSFDLS DVTTPESTKN
       430        440        450        460        470        480
LVESSMVNGG LTSQTKENGL STSQQVPAQR KKLLRAPTLA ELDSSESEEE TLHKSTSSSS
       490        500        510        520        530        540
VSPSFPEEPV LEAVSTRKKP PKFLPISSTP QPERRQPPQR RHSIEKETPT NVRQFLPPSR
       550        560        570        580        590        600
QSSRSLEEFC YPVECLALTV EEVMHIRQVL VKAELEKYQQ YKDIYTALKK GKLCFCCRTR
       610        620        630        640        650        660
RFSFFTWSYT CQFCKRPVCS QCCKKMRLPS KPYSTLPIFS LGPSALQRGE SSMRSEKPST
       670        680        690        700        710        720
AHHRPLRSIA RFSSKSKSMD KSDEELQFPK ELMEDWSTME VCVDCKKFIS EIISSSRRSL
       730        740        750
VLANKRARLK RKTQSFYMSS PGPSEYCPSE RTISEI         10         20         30         40         50         60
MAQAAGPAGG GEPRTEAVGG EGPREPGAAG GAAGGSRDAL SLEEILRLYN QPINEEQAWA
        70         80         90        100        110        120
VCYQCCGSLR AAARRRQPRH RVRSAAQIRV WRDGAVTLAP AADDAGEPPP VAGKLGYSQC
       130        140        150        160        170        180
METEVIESLG IIIYKALDYG LKENEERELS PPLEQLIDHM ANTVEADGSN DEGYEAAEEG
       190        200        210        220        230        240
LGDEDEKRKI SAIRSYRDVM KLCAAHLPTE SDAPNHYQAV CRALFAETME LHTFLTKIKS
       250        260        270        280        290        300
AKENLKKIQE MEKSDESSTD LEELKNADWA RFWVQVMRDL RNGVKLKKVQ ERQYNPLPIE
       310        320        330        340        350        360
YQLTPYEMLM DDIRCKRYTL RKVMVNGDIP PRLKKSAHEI ILDFIRSRPP LNPVSARKLK
       370        380        390        400        410        420
PTPPRPRSLH ERILEEIKAE RKLRPVSPEE IRRSRLAMRP LSMSYSFDLS DVTTPESTKN
       430        440        450        460        470        480
LVESSMVNGG LTSQTKENGL STSQQVPAQR KKLLRAPTLA ELDSSESEEE TLHKSTSSSS
       490        500        510        520        530        540
VSPSFPEEPV LEAVSTRKKP PKFLPISSTP QPERRQPPQR RHSIEKETPT NVRQFLPPSR
       550        560        570        580        590        600
QSSRSLEEFC YPVECLALTV EEVMHIRQVL VKAELEKYQQ YKDIYTALKK GKLCFCCRTR
       610        620        630        640        650        660
RFSFFTWSYT CQFCKRPVCS QCCKKMRLPS KPYSTLPIFS LGPSALQRGE SSMRSEKPST
       670        680        690        700        710        720
AHHRPLRSIA RFSSKSKSMD KSDEELQFPK ELMEDWSTME VCVDCKKFIS EIISSSRRSL
       730        740        750
VLANKRARLK RKTQSFYMSS PGPSEYCPSE RTISEI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q08AE8-2-unknown	MAQAAG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q08AE8-1-unknown	MAQAAG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90463
Q08AE8-2-Acetylation	AQAAGP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q08AE8-2-Acetylation	AQAAGP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q08AE8-2-Acetylation	AQAAGP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q08AE8-2-Acetylation	AQAAGP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111084
Q08AE8-121-unknown	METEVI...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90462
Q08AE8-121-unknown	METEVI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407050
Q08AE8-121-unknown	METEVI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401392
Q08AE8-121-unknown	METEVI...	121		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467943
Q08AE8-121-unknown	METEVI...	121		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101258
Q08AE8-160-unknown	MANTVE...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90464
Q08AE8-160-unknown	MANTVE...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90465
Q08AE8-160-unknown	MANTVE...	160		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000372847
Q08AE8-160-unknown	MANTVE...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101352
Q08AE8-160-unknown	MANTVE...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101351

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IKSAKE	242	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467943
...LKKIQE	249	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467103
...IRCKRY	317	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401392
...TISEI	756	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TISEI	756	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86082
...TISEI	756	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86080
...TISEI	756	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86081

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)