Q12805: EGF-containing fibulin-like extracellular matrix protein 1

General Information

Protein names	- EGF-containing fibulin-like extracellular matrix protein 1 - Extracellular protein S1-5 - Fibrillin-like protein - Fibulin-3 - FIBL-3
Gene names	EFEMP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12805

5 N-termini

8 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of EGF-containing fibulin-like extracellular matrix protein 1 - Isoform 3 of EGF-containing fibulin-like extracellular matrix protein 1 - Isoform 4 of EGF-containing fibulin-like extracellular matrix protein 1 - Isoform 5 of EGF-containing fibulin-like extracellular matrix protein 1

Sequence View

        10         20         30         40         50         60
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK
        70         80         90        100        110        120
CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA
       130        140        150        160        170        180
SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG
       190        200        210        220        230        240
THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS
       250        260        270        280        290        300
PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
       310        320        330        340        350        360
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY
       370        380        390        400        410        420
PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA
       430        440        450        460        470        480
NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS
       490
VLRLTIIVGP FSF         10         20         30         40         50         60
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK
        70         80         90        100        110        120
CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA
       130        140        150        160        170        180
SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG
       190        200        210        220        230        240
THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS
       250        260        270        280        290        300
PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
       310        320        330        340        350        360
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY
       370        380        390        400        410        420
PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA
       430        440        450        460        470        480
NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS
       490
VLRLTIIVGP FSF         10         20         30         40         50         60
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK
        70         80         90        100        110        120
CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA
       130        140        150        160        170        180
SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG
       190        200        210        220        230        240
THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS
       250        260        270        280        290        300
PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
       310        320        330        340        350        360
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY
       370        380        390        400        410        420
PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA
       430        440        450        460        470        480
NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS
       490
VLRLTIIVGP FSF         10         20         30         40         50         60
MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK
        70         80         90        100        110        120
CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA
       130        140        150        160        170        180
SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG
       190        200        210        220        230        240
THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS
       250        260        270        280        290        300
PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
       310        320        330        340        350        360
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY
       370        380        390        400        410        420
PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA
       430        440        450        460        470        480
NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS
       490
VLRLTIIVGP FSF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 8 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q12805-1-unknown	MLKALF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74862
Q12805-1-unknown	MLKALF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74863
Q12805-9-unknown	MLTLAL...	9	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74861
Q12805-9-unknown	MLTLAL...	9	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102058
Q12805-9-unknown	MLTLAL...	9	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102059
Q12805-18-unknown	QDTEET...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12805-18-unknown	QDTEET...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111940
Q12805-18-unknown	QDTEET...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111938
Q12805-18-unknown	QDTEET...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111939
Q12805-59-unknown	MKCVNH...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74864
Q12805-59-unknown	MKCVNH...	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399145
Q12805-59-unknown	MKCVNH...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102246
Q12805-59-unknown	MKCVNH...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102245
Q12805-59-unknown	MKCVNH...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102244
Q12805-124-unknown	AVAGPE...	124		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q12805-124-unknown	AVAGPE...	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180328
Q12805-124-unknown	AVAGPE...	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180331
Q12805-124-unknown	AVAGPE...	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180329
Q12805-124-unknown	AVAGPE...	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180330

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TITYTQ	27	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398387
...TITYTQ	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153741
...TITYTQ	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153742
...ECDIVP	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405686
...ECDIVP	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153901
...ECDIVP	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153899
...ECDIVP	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153900
...GGMKCV	61	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399480
...GGMKCV	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153937
...GGMKCV	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153936
...QPQQET	87	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389319
...QPQQET	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154225
...QPQQET	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154228
...QPQQET	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154227
...QPQQET	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154226
...VAASSM	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398345
...VAASSM	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154433
...VAASSM	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154435
...VAASSM	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154434
...GGGFVA	119	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408195
...GGGFVA	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154564
...GGGFVA	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154566
...GGGFVA	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154565
...HNVCQD	172	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392055
...HNVCQD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155287
...HNVCQD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155290
...HNVCQD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155288
...HNVCQD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155289
...GPFSF	493	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPFSF	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70482
...GPFSF	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70479
...GPFSF	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70480
...GPFSF	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70481

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)