Q12929: Epidermal growth factor receptor kinase substrate 8

General Information

Protein names	- Epidermal growth factor receptor kinase substrate 8
Gene names	EPS8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12929

2 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ TDREHGSKTS AKALYEQRKN YARDSVSSVS
        70         80         90        100        110        120
DISQYRVEHL TTFVLDRKDA MITVDDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE
       130        140        150        160        170        180
SKNELENFPL NTIQHCQAVM HSCSYDSVLA LVCKEPTQNK PDLHLFQCDE VKANLISEDI
       190        200        210        220        230        240
ESAISDSKGG KQKRRPDALR MISNADPSIP PPPRAPAPAP PGTVTQVDVR SRVAAWSAWA
       250        260        270        280        290        300
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR
       310        320        330        340        350        360
KKNKKGKRKG PGEGVLTLRA KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ NPSAADLVHF
       370        380        390        400        410        420
LFTPLNMVVQ ATGGPELASS VLSPLLNKDT IDFLNYTVNG DERQLWMSLG GTWMKARAEW
       430        440        450        460        470        480
PKEQFIPPYV PRFRNGWEPP MLNFMGATME QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS
       490        500        510        520        530        540
SVSEYHPADG YAFSSNIYTR GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY
       550        560        570        580        590        600
DFVARNNSEL SVLKDDILEI LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP
       610        620        630        640        650        660
PYTHTIQKQR MEYGPRPADT PPAPSPPPTP APVPVPLPPS TPAPVPVSKV PANITRQNSS
       670        680        690        700        710        720
SSDSGGSIVR DSQRHKQLPV DRRKSQMEEV QDELIHRLTI GRSAAQKKFH VPRQNVPVIN
       730        740        750        760        770        780
ITYDSTPEDV KTWLQSKGFN PVTVNSLGVL NGAQLFSLNK DELRTVCPEG ARVYSQITVQ
       790        800        810        820
KAALEDSSGS SELQEIMRRR QEKISAAASD SGVESFDEGS SH

Isoforms

- Isoform 2 of Epidermal growth factor receptor kinase substrate 8

Sequence View

        10         20         30         40         50         60
MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ TDREHGSKTS AKALYEQRKN YARDSVSSVS
        70         80         90        100        110        120
DISQYRVEHL TTFVLDRKDA MITVDDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE
       130        140        150        160        170        180
SKNELENFPL NTIQHCQAVM HSCSYDSVLA LVCKEPTQNK PDLHLFQCDE VKANLISEDI
       190        200        210        220        230        240
ESAISDSKGG KQKRRPDALR MISNADPSIP PPPRAPAPAP PGTVTQVDVR SRVAAWSAWA
       250        260        270        280        290        300
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR
       310        320        330        340        350        360
KKNKKGKRKG PGEGVLTLRA KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ NPSAADLVHF
       370        380        390        400        410        420
LFTPLNMVVQ ATGGPELASS VLSPLLNKDT IDFLNYTVNG DERQLWMSLG GTWMKARAEW
       430        440        450        460        470        480
PKEQFIPPYV PRFRNGWEPP MLNFMGATME QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS
       490        500        510        520        530        540
SVSEYHPADG YAFSSNIYTR GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY
       550        560        570        580        590        600
DFVARNNSEL SVLKDDILEI LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP
       610        620        630        640        650        660
PYTHTIQKQR MEYGPRPADT PPAPSPPPTP APVPVPLPPS TPAPVPVSKV PANITRQNSS
       670        680        690        700        710        720
SSDSGGSIVR DSQRHKQLPV DRRKSQMEEV QDELIHRLTI GRSAAQKKFH VPRQNVPVIN
       730        740        750        760        770        780
ITYDSTPEDV KTWLQSKGFN PVTVNSLGVL NGAQLFSLNK DELRTVCPEG ARVYSQITVQ
       790        800        810        820
KAALEDSSGS SELQEIMRRR QEKISAAASD SGVESFDEGS SH

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q12929-1-unknown	MNGHIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12929-261-unknown	MMAARI...	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441888
Q12929-261-unknown	MMAARI...	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437806

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQYRVE	67	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445815
...QYRVEH	68	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444613
...QYRVEH	68	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438668
...LIDLES	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440591
...ELENFP	128	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445235
...EGSSH	822	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

TopFIND

Q12929: Epidermal growth factor receptor kinase substrate 8

General Information

2

N-termini

5

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

2 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates