Q12968: Nuclear factor of activated T-cells, cytoplasmic 3

General Information

Protein names	- Nuclear factor of activated T-cells, cytoplasmic 3 - NF-ATc3 - NFATc3 - NFATx - T-cell transcription factor NFAT4 {ECO:0000303\|PubMed:7749981} - NF-AT4 {ECO:0000303\|PubMed:7749981} - NF-AT4c {ECO:0000303\|PubMed:7749981}
Gene names	NFATC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12968

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear factor of activated T-cells, cytoplasmic 3 - Isoform 3 of Nuclear factor of activated T-cells, cytoplasmic 3 - Isoform 4 of Nuclear factor of activated T-cells, cytoplasmic 3 - Isoform 5 of Nuclear factor of activated T-cells, cytoplasmic 3 - Isoform 6 of Nuclear factor of activated T-cells, cytoplasmic 3

Sequence View

        10         20         30         40         50         60
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL
        70         80         90        100        110        120
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
       130        140        150        160        170        180
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
       190        200        210        220        230        240
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS
       250        260        270        280        290        300
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
       310        320        330        340        350        360
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD
       370        380        390        400        410        420
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
       430        440        450        460        470        480
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM
       490        500        510        520        530        540
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
       550        560        570        580        590        600
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP
       610        620        630        640        650        660
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
       670        680        690        700        710        720
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHREEI DLSSVPSLPV
       730        740        750        760        770        780
PHPAQTQRPS SDSGCSHDSV LSGQRSLICS IPQTYASMVT SSHLPQLQCR DESVSKEQHM
       790        800        810        820        830        840
IPSPIVHQPF QVTPTPPVGS SYQPMQTNVV YNGPTCLPIN AASSQEFDSV LFQQDATLSG
       850        860        870        880        890        900
LVNLGCQPLS SIPFHSSNSG STGHLLAHTP HSVHTLPHLQ SMGYHCSNTG QRSLSSPVAD
       910        920        930        940        950        960
QITGQPSSQL QPITYGPSHS GSATTASPAA SHPLASSPLS GPPSPQLQPM PYQSPSSGTA
       970        980        990       1000       1010       1020
SSPSPATRMH SGQHSTQAQS TGQGGLSAPS SLICHSLCDP ASFPPDGATV SIKPEPEDRE
      1030       1040       1050       1060       1070
PNFATIGLQD ITLDDVNEII GRDMSQISVS QGAGVSRQAP LPSPESLDLG RSDGL         10         20         30         40         50         60
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL
        70         80         90        100        110        120
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
       130        140        150        160        170        180
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
       190        200        210        220        230        240
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS
       250        260        270        280        290        300
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
       310        320        330        340        350        360
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD
       370        380        390        400        410        420
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
       430        440        450        460        470        480
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM
       490        500        510        520        530        540
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
       550        560        570        580        590        600
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP
       610        620        630        640        650        660
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
       670        680        690        700        710        720
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHREEI DLSSVPSLPV
       730        740        750        760        770        780
PHPAQTQRPS SDSGCSHDSV LSGQRSLICS IPQTYASMVT SSHLPQLQCR DESVSKEQHM
       790        800        810        820        830        840
IPSPIVHQPF QVTPTPPVGS SYQPMQTNVV YNGPTCLPIN AASSQEFDSV LFQQDATLSG
       850        860        870        880        890        900
LVNLGCQPLS SIPFHSSNSG STGHLLAHTP HSVHTLPHLQ SMGYHCSNTG QRSLSSPVAD
       910        920        930        940        950        960
QITGQPSSQL QPITYGPSHS GSATTASPAA SHPLASSPLS GPPSPQLQPM PYQSPSSGTA
       970        980        990       1000       1010       1020
SSPSPATRMH SGQHSTQAQS TGQGGLSAPS SLICHSLCDP ASFPPDGATV SIKPEPEDRE
      1030       1040       1050       1060       1070
PNFATIGLQD ITLDDVNEII GRDMSQISVS QGAGVSRQAP LPSPESLDLG RSDGL         10         20         30         40         50         60
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL
        70         80         90        100        110        120
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
       130        140        150        160        170        180
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
       190        200        210        220        230        240
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS
       250        260        270        280        290        300
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
       310        320        330        340        350        360
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD
       370        380        390        400        410        420
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
       430        440        450        460        470        480
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM
       490        500        510        520        530        540
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
       550        560        570        580        590        600
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP
       610        620        630        640        650        660
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
       670        680        690        700        710        720
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHREEI DLSSVPSLPV
       730        740        750        760        770        780
PHPAQTQRPS SDSGCSHDSV LSGQRSLICS IPQTYASMVT SSHLPQLQCR DESVSKEQHM
       790        800        810        820        830        840
IPSPIVHQPF QVTPTPPVGS SYQPMQTNVV YNGPTCLPIN AASSQEFDSV LFQQDATLSG
       850        860        870        880        890        900
LVNLGCQPLS SIPFHSSNSG STGHLLAHTP HSVHTLPHLQ SMGYHCSNTG QRSLSSPVAD
       910        920        930        940        950        960
QITGQPSSQL QPITYGPSHS GSATTASPAA SHPLASSPLS GPPSPQLQPM PYQSPSSGTA
       970        980        990       1000       1010       1020
SSPSPATRMH SGQHSTQAQS TGQGGLSAPS SLICHSLCDP ASFPPDGATV SIKPEPEDRE
      1030       1040       1050       1060       1070
PNFATIGLQD ITLDDVNEII GRDMSQISVS QGAGVSRQAP LPSPESLDLG RSDGL         10         20         30         40         50         60
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL
        70         80         90        100        110        120
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
       130        140        150        160        170        180
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
       190        200        210        220        230        240
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS
       250        260        270        280        290        300
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
       310        320        330        340        350        360
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD
       370        380        390        400        410        420
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
       430        440        450        460        470        480
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM
       490        500        510        520        530        540
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
       550        560        570        580        590        600
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP
       610        620        630        640        650        660
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
       670        680        690        700        710        720
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHREEI DLSSVPSLPV
       730        740        750        760        770        780
PHPAQTQRPS SDSGCSHDSV LSGQRSLICS IPQTYASMVT SSHLPQLQCR DESVSKEQHM
       790        800        810        820        830        840
IPSPIVHQPF QVTPTPPVGS SYQPMQTNVV YNGPTCLPIN AASSQEFDSV LFQQDATLSG
       850        860        870        880        890        900
LVNLGCQPLS SIPFHSSNSG STGHLLAHTP HSVHTLPHLQ SMGYHCSNTG QRSLSSPVAD
       910        920        930        940        950        960
QITGQPSSQL QPITYGPSHS GSATTASPAA SHPLASSPLS GPPSPQLQPM PYQSPSSGTA
       970        980        990       1000       1010       1020
SSPSPATRMH SGQHSTQAQS TGQGGLSAPS SLICHSLCDP ASFPPDGATV SIKPEPEDRE
      1030       1040       1050       1060       1070
PNFATIGLQD ITLDDVNEII GRDMSQISVS QGAGVSRQAP LPSPESLDLG RSDGL         10         20         30         40         50         60
MTTANCGAHD ELDFKLVFGE DGAPAPPPPG SRPADLEPDD CASIYIFNVD PPPSTLTTPL
        70         80         90        100        110        120
CLPHHGLPSH SSVLSPSFQL QSHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
       130        140        150        160        170        180
HQELDAHEDD LQINDPEREF LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
       190        200        210        220        230        240
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEETWHQQYG LGHSLSPRQS
       250        260        270        280        290        300
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
       310        320        330        340        350        360
PRGSVTEDTW LNASVHGGSG LGPAVFPFQY CVETDIPLKT RKTSEDQAAI LPGKLELCSD
       370        380        390        400        410        420
DQGSLSPARE TSIDDGLGSQ YPLKKDSCGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
       430        440        450        460        470        480
DWPLPAHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YNEKPINLQM
       490        500        510        520        530        540
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
       550        560        570        580        590        600
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPSGKVL SLQIASIPVE CSQRSAQELP
       610        620        630        640        650        660
HIEKYSINSC SVNGGHEMVV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
       670        680        690        700        710        720
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHREEI DLSSVPSLPV
       730        740        750        760        770        780
PHPAQTQRPS SDSGCSHDSV LSGQRSLICS IPQTYASMVT SSHLPQLQCR DESVSKEQHM
       790        800        810        820        830        840
IPSPIVHQPF QVTPTPPVGS SYQPMQTNVV YNGPTCLPIN AASSQEFDSV LFQQDATLSG
       850        860        870        880        890        900
LVNLGCQPLS SIPFHSSNSG STGHLLAHTP HSVHTLPHLQ SMGYHCSNTG QRSLSSPVAD
       910        920        930        940        950        960
QITGQPSSQL QPITYGPSHS GSATTASPAA SHPLASSPLS GPPSPQLQPM PYQSPSSGTA
       970        980        990       1000       1010       1020
SSPSPATRMH SGQHSTQAQS TGQGGLSAPS SLICHSLCDP ASFPPDGATV SIKPEPEDRE
      1030       1040       1050       1060       1070
PNFATIGLQD ITLDDVNEII GRDMSQISVS QGAGVSRQAP LPSPESLDLG RSDGL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q12968-1-unknown	MTTANC...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82688
Q12968-1-unknown	MTTANC...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82689
Q12968-1-unknown	MTTANC...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82690
Q12968-1-unknown	MTTANC...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82691
Q12968-1-unknown	MTTANC...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82692
Q12968-2-unknown	MTTANC...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111600
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111601
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111602
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111603
Q12968-2-Acetylation	TTANCG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111604
Q12968-194-unknown	SELNEA...	194		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2142
Q12968-194-unknown	SELNEA...	194		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146392
Q12968-194-unknown	SELNEA...	194		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146393
Q12968-194-unknown	SELNEA...	194		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146394
Q12968-194-unknown	SELNEA...	194		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146395
Q12968-194-unknown	SELNEA...	194		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146396

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YDDVDS	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2142
...YDDVDS	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129697
...YDDVDS	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129698
...YDDVDS	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129699
...YDDVDS	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129700
...YDDVDS	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129701
...RSDGL	1075	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	193	DVDS.\|.SELN	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> NFAC3_HUMAN @193

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)