Q13114: TNF receptor-associated factor 3

General Information

Protein names	- TNF receptor-associated factor 3 - 2.3.2.27 - CAP-1 - CD40 receptor-associated factor 1 - CRAF1 - CD40-binding protein - CD40BP - LMP1-associated protein 1 - LAP1 - RING-type E3 ubiquitin transferase TRAF3 {ECO:0000305}
Gene names	TRAF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13114

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL
        70         80         90        100        110        120
CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE
       130        140        150        160        170        180
SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC
       190        200        210        220        230        240
KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV
       250        260        270        280        290        300
FQGTNQQIKA HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI
       310        320        330        340        350        360
EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM KSSVESLQNR
       370        380        390        400        410        420
VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA DMDLRFQVLE TASYNGVLIW
       430        440        450        460        470        480
KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF GYKMCARVYL NGDGMGKGTH LSLFFVIMRG
       490        500        510        520        530        540
EYDALLPWPF KQKVTLMLMD QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ
       550        560
TVLENGTYIK DDTIFIKVIV DTSDLPDP

Isoforms

- Isoform 2 of TNF receptor-associated factor 3

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13114-1-unknown	MESSKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13114-1-unknown	MESSKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92946
Q13114-349-unknown	SMKSSV...	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2155
Q13114-349-unknown	SMKSSV...	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149016
Q13114-369-unknown	KSAGQV...	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2157
Q13114-369-unknown	KSAGQV...	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149489

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WEEADS	348	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2155
...WEEADS	348	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132399
...LESVDK	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2157
...LESVDK	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132873
...DLPDP	568	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DLPDP	568	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88564

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	348	EADS.\|.SMKS	inferred from experiment	unknown	MEROPS	Kim HH	Lee ZH et al.:Caspase-mediated cleavage of TR... (C14.003)	11261798,
CASP3_HUMAN	368	SVDK.\|.KSAG	inferred from experiment	unknown	MEROPS	Kim HH	Lee ZH et al.:Caspase-mediated cleavage of TR... (C14.003)	11261798,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)