TopFIND 4.0

Q13131: 5'-AMP-activated protein kinase catalytic subunit alpha-1

General Information

Protein names
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- AMPK subunit alpha-1
- 2.7.11.1 {ECO:0000250|UniProtKB:P54645}
- Acetyl-CoA carboxylase kinase
- ACACA kinase
- 2.7.11.27 {ECO:0000250|UniProtKB:P54645}
- Hydroxymethylglutaryl-CoA reductase kinase
- HMGCR kinase
- 2.7.11.31 {ECO:0000250|UniProtKB:P54645}
- Tau-protein kinase PRKAA1
- 2.7.11.26
Gene names PRKAA1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q13131

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 
        70         80         90        100        110        120 
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 
       130        140        150        160        170        180 
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 
       190        200        210        220        230        240 
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 
       250        260        270        280        290        300 
IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 
       310        320        330        340        350        360 
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 
       370        380        390        400        410        420 
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 
       430        440        450        460        470        480 
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE 
       490        500        510        520        530        540 
ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG 
       550    
SHTIEFFEMC ANLIKILAQ

Isoforms

- Isoform 2 of 5'-AMP-activated protein kinase catalytic subunit alpha-1

Sequence View

        10         20         30         40         50         60 
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 
        70         80         90        100        110        120 
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 
       130        140        150        160        170        180 
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 
       190        200        210        220        230        240 
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 
       250        260        270        280        290        300 
IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 
       310        320        330        340        350        360 
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 
       370        380        390        400        410        420 
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 
       430        440        450        460        470        480 
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE 
       490        500        510        520        530        540 
ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG 
       550    
SHTIEFFEMC ANLIKILAQ



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Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q13131-1-unknown MRRLSS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q13131-1-unknown MRRLSS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt65899

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KILAQ 559 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...KILAQ 559 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt61517

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)