Q13153: Serine/threonine-protein kinase PAK 1 {ECO:0000303|PubMed:8805275}

General Information

Protein names	- Serine/threonine-protein kinase PAK 1 {ECO:0000303\|PubMed:8805275} - 2.7.11.1 {ECO:0000269\|PubMed:10551809, ECO:0000269\|PubMed:22153498, ECO:0000269\|PubMed:9032240} - Alpha-PAK {ECO:0000303\|PubMed:9528787} - p21-activated kinase 1 {ECO:0000303\|PubMed:9395435} - PAK-1 - p65-PAK {ECO:0000250\|UniProtKB:P35465}
Gene names	PAK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13153

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK KDRFYRSILP
        70         80         90        100        110        120
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN
       130        140        150        160        170        180
PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNALN VKAVSETPAV PPVSEDEDDD
       190        200        210        220        230        240
DDDATPPPVI APRPEHTKSV YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE
       250        260        270        280        290        300
KQKKKPKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ
       310        320        330        340        350        360
MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC
       370        380        390        400        410        420
MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK
       430        440        450        460        470        480
RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMIEG EPPYLNENPL RALYLIATNG
       490        500        510        520        530        540
TPELQNPEKL SAIFRDFLNR CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA

TKNNH

Isoforms

- Isoform 2 of Serine/threonine-protein kinase PAK 1

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13153-2-unknown	MSNNGL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13153-1-unknown	MSNNGL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84173
Q13153-2-Acetylation	SNNGLD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13153-2-Acetylation	SNNGLD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13153-2-Acetylation	SNNGLD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110337
Q13153-204-	SVIEPL...	204			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13153-204-unknown	SVIEPL...	204		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176388

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TKNNH	545	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)