Q13188: Serine/threonine-protein kinase 3

General Information

Protein names	- Serine/threonine-protein kinase 3 - 2.7.11.1 - Mammalian STE20-like protein kinase 2 - MST-2 - STE20-like kinase MST2 - Serine/threonine-protein kinase Krs-1 - Serine/threonine-protein kinase 3 36kDa subunit - MST2/N - Serine/threonine-protein kinase 3 20kDa subunit - MST2/C
Gene names	STK3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13188

2 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG QVVAIKQVPV
        70         80         90        100        110        120
ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME YCGAGSVSDI IRLRNKTLIE
       130        140        150        160        170        180
DEIATILKST LKGLEYLHFM RKIHRDIKAG NILLNTEGHA KLADFGVAGQ LTDTMAKRNT
       190        200        210        220        230        240
VIGTPFWMAP EVIQEIGYNC VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT
       250        260        270        280        290        300
FRKPELWSDD FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK
       310        320        330        340        350        360
RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM IEHNSTMLES
       370        380        390        400        410        420
DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ DFKNKSHENC NQNMHEPFPM
       430        440        450        460        470        480
SKNVFPDNWK VPQDGDFDFL KNLSLEELQM RLKALDPMME REIEELRQRY TAKRQPILDA
       490
MDAKKRRQQN F

Isoforms

- Isoform 2 of Serine/threonine-protein kinase 3

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q13188-1-Acetylation	MEQPPA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13188-323-unknown	SHTMVK...	323		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13188-323-unknown	SHTMVK...	323		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2164
Q13188-323-unknown	SHTMVK...	323		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116155

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDELDS	322	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDELDS	322	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2164
...EDELDS	322	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92391
...GTMRAT	339	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428014
...GTMRAT	339	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113962
...RQQNF	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RQQNF	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86546

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	322	ELDS.\|.SHTM	inferred from experiment	unknown	MEROPS	Yonehara S	Lee KK et al.:Proteolytic activation of MST/K... (C14.003)	9662336,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)