Q13315: Serine-protein kinase ATM

General Information

Protein names	- Serine-protein kinase ATM - 2.7.11.1 {ECO:0000269\|PubMed:16858402, ECO:0000269\|PubMed:28508083, ECO:0000269\|PubMed:8988033, ECO:0000269\|PubMed:9843217} - Ataxia telangiectasia mutated - A-T mutated
Gene names	ATM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13315

6 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLVLNDLLI CCRQLEHDRA TERKKEVEKF KRLIRDPETI KHLDRHSDSK QGKYLNWDAV
        70         80         90        100        110        120
FRFLQKYIQK ETECLRIAKP NVSASTQASR QKKMQEISSL VKYFIKCANR RAPRLKCQEL
       130        140        150        160        170        180
LNYIMDTVKD SSNGAIYGAD CSNILLKDIL SVRKYWCEIS QQQWLELFSV YFRLYLKPSQ
       190        200        210        220        230        240
DVHRVLVARI IHAVTKGCCS QTDGLNSKFL DFFSKAIQCA RQEKSSSGLN HILAALTIFL
       250        260        270        280        290        300
KTLAVNFRIR VCELGDEILP TLLYIWTQHR LNDSLKEVII ELFQLQIYIH HPKGAKTQEK
       310        320        330        340        350        360
GAYESTKWRS ILYNLYDLLV NEISHIGSRG KYSSGFRNIA VKENLIELMA DICHQVFNED
       370        380        390        400        410        420
TRSLEISQSY TTTQRESSDY SVPCKRKKIE LGWEVIKDHL QKSQNDFDLV PWLQIATQLI
       430        440        450        460        470        480
SKYPASLPNC ELSPLLMILS QLLPQQRHGE RTPYVLRCLT EVALCQDKRS NLESSQKSDL
       490        500        510        520        530        540
LKLWNKIWCI TFRGISSEQI QAENFGLLGA IIQGSLVEVD REFWKLFTGS ACRPSCPAVC
       550        560        570        580        590        600
CLTLALTTSI VPGTVKMGIE QNMCEVNRSF SLKESIMKWL LFYQLEGDLE NSTEVPPILH
       610        620        630        640        650        660
SNFPHLVLEK ILVSLTMKNC KAAMNFFQSV PECEHHQKDK EELSFSEVEE LFLQTTFDKM
       670        680        690        700        710        720
DFLTIVRECG IEKHQSSIGF SVHQNLKESL DRCLLGLSEQ LLNNYSSEIT NSETLVRCSR
       730        740        750        760        770        780
LLVGVLGCYC YMGVIAEEEA YKSELFQKAK SLMQCAGESI TLFKNKTNEE FRIGSLRNMM
       790        800        810        820        830        840
QLCTRCLSNC TKKSPNKIAS GFFLRLLTSK LMNDIADICK SLASFIKKPF DRGEVESMED
       850        860        870        880        890        900
DTNGNLMEVE DQSSMNLFND YPDSSVSDAN EPGESQSTIG AINPLAEEYL SKQDLLFLDM
       910        920        930        940        950        960
LKFLCLCVTT AQTNTVSFRA ADIRRKLLML IDSSTLEPTK SLHLHMYLML LKELPGEEYP
       970        980        990       1000       1010       1020
LPMEDVLELL KPLSNVCSLY RRDQDVCKTI LNHVLHVVKN LGQSNMDSEN TRDAQGQFLT
      1030       1040       1050       1060       1070       1080
VIGAFWHLTK ERKYIFSVRM ALVNCLKTLL EADPYSKWAI LNVMGKDFPV NEVFTQFLAD
      1090       1100       1110       1120       1130       1140
NHHQVRMLAA ESINRLFQDT KGDSSRLLKA LPLKLQQTAF ENAYLKAQEG MREMSHSAEN
      1150       1160       1170       1180       1190       1200
PETLDEIYNR KSVLLTLIAV VLSCSPICEK QALFALCKSV KENGLEPHLV KKVLEKVSET
      1210       1220       1230       1240       1250       1260
FGYRRLEDFM ASHLDYLVLE WLNLQDTEYN LSSFPFILLN YTNIEDFYRS CYKVLIPHLV
      1270       1280       1290       1300       1310       1320
IRSHFDEVKS IANQIQEDWK SLLTDCFPKI LVNILPYFAY EGTRDSGMAQ QRETATKVYD
      1330       1340       1350       1360       1370       1380
MLKSENLLGK QIDHLFISNL PEIVVELLMT LHEPANSSAS QSTDLCDFSG DLDPAPNPPH
      1390       1400       1410       1420       1430       1440
FPSHVIKATF AYISNCHKTK LKSILEILSK SPDSYQKILL AICEQAAETN NVYKKHRILK
      1450       1460       1470       1480       1490       1500
IYHLFVSLLL KDIKSGLGGA WAFVLRDVIY TLIHYINQRP SCIMDVSLRS FSLCCDLLSQ
      1510       1520       1530       1540       1550       1560
VCQTAVTYCK DALENHLHVI VGTLIPLVYE QVEVQKQVLD LLKYLVIDNK DNENLYITIK
      1570       1580       1590       1600       1610       1620
LLDPFPDHVV FKDLRITQQK IKYSRGPFSL LEEINHFLSV SVYDALPLTR LEGLKDLRRQ
      1630       1640       1650       1660       1670       1680
LELHKDQMVD IMRASQDNPQ DGIMVKLVVN LLQLSKMAIN HTGEKEVLEA VGSCLGEVGP
      1690       1700       1710       1720       1730       1740
IDFSTIAIQH SKDASYTKAL KLFEDKELQW TFIMLTYLNN TLVEDCVKVR SAAVTCLKNI
      1750       1760       1770       1780       1790       1800
LATKTGHSFW EIYKMTTDPM LAYLQPFRTS RKKFLEVPRF DKENPFEGLD DINLWIPLSE
      1810       1820       1830       1840       1850       1860
NHDIWIKTLT CAFLDSGGTK CEILQLLKPM CEVKTDFCQT VLPYLIHDIL LQDTNESWRN
      1870       1880       1890       1900       1910       1920
LLSTHVQGFF TSCLRHFSQT SRSTTPANLD SESEHFFRCC LDKKSQRTML AVVDYMRRQK
      1930       1940       1950       1960       1970       1980
RPSSGTIFND AFWLDLNYLE VAKVAQSCAA HFTALLYAEI YADKKSMDDQ EKRSLAFEEG
      1990       2000       2010       2020       2030       2040
SQSTTISSLS EKSKEETGIS LQDLLLEIYR SIGEPDSLYG CGGGKMLQPI TRLRTYEHEA
      2050       2060       2070       2080       2090       2100
MWGKALVTYD LETAIPSSTR QAGIIQALQN LGLCHILSVY LKGLDYENKD WCPELEELHY
      2110       2120       2130       2140       2150       2160
QAAWRNMQWD HCTSVSKEVE GTSYHESLYN ALQSLRDREF STFYESLKYA RVKEVEEMCK
      2170       2180       2190       2200       2210       2220
RSLESVYSLY PTLSRLQAIG ELESIGELFS RSVTHRQLSE VYIKWQKHSQ LLKDSDFSFQ
      2230       2240       2250       2260       2270       2280
EPIMALRTVI LEILMEKEMD NSQRECIKDI LTKHLVELSI LARTFKNTQL PERAIFQIKQ
      2290       2300       2310       2320       2330       2340
YNSVSCGVSE WQLEEAQVFW AKKEQSLALS ILKQMIKKLD ASCAANNPSL KLTYTECLRV
      2350       2360       2370       2380       2390       2400
CGNWLAETCL ENPAVIMQTY LEKAVEVAGN YDGESSDELR NGKMKAFLSL ARFSDTQYQR
      2410       2420       2430       2440       2450       2460
IENYMKSSEF ENKQALLKRA KEEVGLLREH KIQTNRYTVK VQRELELDEL ALRALKEDRK
      2470       2480       2490       2500       2510       2520
RFLCKAVENY INCLLSGEEH DMWVFRLCSL WLENSGVSEV NGMMKRDGMK IPTYKFLPLM
      2530       2540       2550       2560       2570       2580
YQLAARMGTK MMGGLGFHEV LNNLISRISM DHPHHTLFII LALANANRDE FLTKPEVARR
      2590       2600       2610       2620       2630       2640
SRITKNVPKQ SSQLDEDRTE AANRIICTIR SRRPQMVRSV EALCDAYIIL ANLDATQWKT
      2650       2660       2670       2680       2690       2700
QRKGINIPAD QPITKLKNLE DVVVPTMEIK VDHTGEYGNL VTIQSFKAEF RLAGGVNLPK
      2710       2720       2730       2740       2750       2760
IIDCVGSDGK ERRQLVKGRD DLRQDAVMQQ VFQMCNTLLQ RNTETRKRKL TICTYKVVPL
      2770       2780       2790       2800       2810       2820
SQRSGVLEWC TGTVPIGEFL VNNEDGAHKR YRPNDFSAFQ CQKKMMEVQK KSFEEKYEVF
      2830       2840       2850       2860       2870       2880
MDVCQNFQPV FRYFCMEKFL DPAIWFEKRL AYTRSVATSS IVGYILGLGD RHVQNILINE
      2890       2900       2910       2920       2930       2940
QSAELVHIDL GVAFEQGKIL PTPETVPFRL TRDIVDGMGI TGVEGVFRRC CEKTMEVMRN
      2950       2960       2970       2980       2990       3000
SQETLLTIVE VLLYDPLFDW TMNPLKALYL QQRPEDETEL HPTLNADDQE CKRNLSDIDQ
      3010       3020       3030       3040       3050
SFNKVAERVL MRLQEKLKGV EEGTVLSVGG QVNLLIQQAI DPKNLSRLFP GWKAWV

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13315-2-unknown	MSLVLN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13315-2-Acetylation	SLVLND...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13315-2-Acetylation	SLVLND...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13315-2-Acetylation	SLVLND...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13315-2-Acetylation	SLVLND...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13315-864-unknown	SSVSDA...	864		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2171
Q13315-864-	SSVSDA...	864			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13315-1332-unknown	IDHLFI...	1332		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434327
Q13315-2917-unknown	GMGITG...	2917		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2172

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRQKKM	93	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432318
...SSNGAI	135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469471
...LNSKFL	209	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433955
...NDYPDS	863	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2171
...LCDFSG	1369	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435747
...RDIVDG	2916	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2172
...WKAWV	3056	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	863	YPDS.\|.SSVS	inferred from experiment	unknown	MEROPS	Jackson SP	Smith GC et al.:Cleavage and inactivation of AT... (C14.003)	10454555,
CASP3_HUMAN	2916	IVDG.\|.GMGI	inferred from experiment	unknown	MEROPS	Jackson SP	Smith GC et al.:Cleavage and inactivation of AT... (C14.003)	10454555,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)