Q13421: Mesothelin

General Information

Protein names	- Mesothelin - CAK1 antigen - Pre-pro-megakaryocyte-potentiating factor - Megakaryocyte-potentiating factor - MPF - Mesothelin, cleaved form
Gene names	MSLN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13421

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mesothelin - Isoform 3 of Mesothelin - Isoform 4 of Mesothelin

Sequence View

        10         20         30         40         50         60
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS
        70         80         90        100        110        120
LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL
       130        140        150        160        170        180
DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA
       190        200        210        220        230        240
DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW
       250        260        270        280        290        300
SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT
       310        320        330        340        350        360
ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY
       370        380        390        400        410        420
PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA
       430        440        450        460        470        480
TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ
       490        500        510        520        530        540
LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL
       550        560        570        580        590        600
PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS
       610        620        630
MQEALSGTPC LLGPGPVLTV LALLLASTLA         10         20         30         40         50         60
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS
        70         80         90        100        110        120
LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL
       130        140        150        160        170        180
DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA
       190        200        210        220        230        240
DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW
       250        260        270        280        290        300
SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT
       310        320        330        340        350        360
ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY
       370        380        390        400        410        420
PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA
       430        440        450        460        470        480
TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ
       490        500        510        520        530        540
LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL
       550        560        570        580        590        600
PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS
       610        620        630
MQEALSGTPC LLGPGPVLTV LALLLASTLA         10         20         30         40         50         60
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS
        70         80         90        100        110        120
LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL
       130        140        150        160        170        180
DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA
       190        200        210        220        230        240
DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW
       250        260        270        280        290        300
SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT
       310        320        330        340        350        360
ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY
       370        380        390        400        410        420
PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA
       430        440        450        460        470        480
TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ
       490        500        510        520        530        540
LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL
       550        560        570        580        590        600
PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS
       610        620        630
MQEALSGTPC LLGPGPVLTV LALLLASTLA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13421-1-unknown	MALPTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81626
Q13421-1-unknown	MALPTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81627
Q13421-1-unknown	MALPTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81628
Q13421-37-unknown	LAGETG...	37	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13421-37-unknown	LAGETG...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115314
Q13421-37-unknown	LAGETG...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115315
Q13421-296-unknown	EVEKTA...	296	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13421-296-unknown	EVEKTA...	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116126
Q13421-296-unknown	EVEKTA...	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116127
Q13421-296-unknown	EVEKTA...	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116128

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RQPERT	286	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RQPERT	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92232
...RQPERT	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92233
...RQPERT	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92234
...QEALSG	606	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QEALSG	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93126
...QEALSG	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93127
...ASTLA	630	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77246
...ASTLA	630	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77244

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)