Q13496: Myotubularin

General Information

Protein names	- Myotubularin - Phosphatidylinositol-3,5-bisphosphate 3-phosphatase - 3.1.3.95 {ECO:0000269\|PubMed:12646134, ECO:0000269\|PubMed:14722070} - Phosphatidylinositol-3-phosphate phosphatase - 3.1.3.64 {ECO:0000269\|PubMed:10900271, ECO:0000269\|PubMed:11001925, ECO:0000269\|PubMed:12646134, ECO:0000269\|PubMed:12847286, ECO:0000269\|PubMed:14722070}
Gene names	MTM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13496

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK
        70         80         90        100        110        120
GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDMRNLR
       130        140        150        160        170        180
FALKQEGHSR RDMFEILTRY AFPLAHSLPL FAFLNEEKFN VDGWTVYNPV EEYRRQGLPN
       190        200        210        220        230        240
HHWRITFINK CYELCDTYPA LLVVPYRASD DDLRRVATFR SRNRIPVLSW IHPENKTVIV
       250        260        270        280        290        300
RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ ISKLTIYDAR PSVNAVANKA TGGGYESDDA
       310        320        330        340        350        360
YHNAELFFLD IHNIHVMRES LKKVKDIVYP NVEESHWLSS LESTHWLEHI KLVLTGAIQV
       370        380        390        400        410        420
ADKVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRSI EGFEILVQKE WISFGHKFAS
       430        440        450        460        470        480
RIGHGDKNHT DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE QFLIIILDHL YSCRFGTFLF
       490        500        510        520        530        540
NCESARERQK VTERTVSLWS LINSNKEKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR
       550        560        570        580        590        600
WNPRIKQQQP NPVEQRYMEL LALRDEYIKR LEELQLANSA KLSDPPTSPS SPSQMMPHVQ

THF

Isoforms

- Isoform 2 of Myotubularin

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13496-1-unknown	MASAST...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13496-96-unknown	MGGATS...	96	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444015
Q13496-96-unknown	MGGATS...	96	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472814
Q13496-116-unknown	MRNLRF...	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439784
Q13496-116-unknown	MRNLRF...	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471949

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VEEYRR	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400699
...VEEYRR	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469941
...VQTHF	603	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)