Q13501: Sequestosome-1

General Information

Protein names	- Sequestosome-1 - EBI3-associated protein of 60 kDa - EBIAP - p60 - Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa - Ubiquitin-binding protein p62
Gene names	SQSTM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13501

12 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP
        70         80         90        100        110        120
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN
       130        140        150        160        170        180
MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS
       190        200        210        220        230        240
HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV
       250        260        270        280        290        300
GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV
       310        320        330        340        350        360
EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE
       370        380        390        400        410        420
SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK
       430        440
NYDIGAALDT IQYSKHPPPL

Isoforms

- Isoform 2 of Sequestosome-1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13501-2-unknown	MASLTV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13501-2-Acetylation	ASLTVK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13501-2-Acetylation	ASLTVK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13501-2-Acetylation	ASLTVK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13501-85-unknown	MAMSYV...	85		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90589
Q13501-120-	NMVHPN...	120			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13501-120-unknown	NMVHPN...	120		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178242
Q13501-330-unknown	NCSGGD...	330		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1282
Q13501-330-unknown	NCSGGD...	330		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148279
Q13501-332-unknown	SGGDDD...	332		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175605
Q13501-332-	SGGDDD...	332			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13501-333-unknown	GGDDDW...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175607
Q13501-333-	GGDDDW...	333			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13501-381-	ALYPHL...	381			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q13501-381-unknown	ALYPHL...	381		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177501

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QMESDN	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1282
...QMESDN	329	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131649
...HPPPL	440	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HPPPL	440	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86207

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	329	ESDN.\|.NCSG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)