Q13586: Stromal interaction molecule 1

General Information

Protein names	- Stromal interaction molecule 1
Gene names	STIM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13586

6 N-termini

10 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDVCVRLALW LLWGLLLHQG QSLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED
        70         80         90        100        110        120
EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL
       130        140        150        160        170        180
WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK
       190        200        210        220        230        240
MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH
       250        260        270        280        290        300
MKKMMKDLEG LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL
       310        320        330        340        350        360
KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW LQLTHEVEVQ
       370        380        390        400        410        420
YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL TAKQALSEVT
       430        440        450        460        470        480
AALRERLHRW QQIEILCGFQ IVNNPGIHSL VAALNIDPSW MGSTRPNPAH FIMTDDVDDM
       490        500        510        520        530        540
DEEIVSPLSM QSPSLQSSVR QRLTEPQHGL GSQRDLTHSD SESSLHMSDR QRVAPKPPQM
       550        560        570        580        590        600
SRAADEALNA MTSNGSHRLI EGVHPGSLVE KLPDSPALAK KALLALNHGL DKAHSLMELS
       610        620        630        640        650        660
PSAPPGGSPH LDSSRSHSPS SPDPDTPSPV GDSRALQASR NTRIPHLAGK KAVAEEDNGS
       670        680
IGEETDSSPG RKKFPLKIFK KPLKK

Isoforms

- Isoform 2 of Stromal interaction molecule 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

6 N-termini - 10 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13586-23-unknown	LSHSHS...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432210
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434848
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433949
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431878
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434200
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431191
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432378
Q13586-75-unknown	MDDDAN...	75	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432383
Q13586-174-unknown	MTGTVL...	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434767
Q13586-489-	SMQSPS...	489		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13586-489-unknown	SMQSPS...	489		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13586-490-	MQSPSL...	490		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13586-490-	MQSPSL...	490		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...WKSSEV	128	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434200
...VVQWLI	141	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432383
...YEETFR	154	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431878
...ETFRKL	156	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431191
...KMTDRS	184	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432210
...RQKLQL	191	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432378
...NHLKDF	213	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433949
...SRNTRI	643	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000433266
...KPLKK	685	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KPLKK	685		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KPLKK	685		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KPLKK	685		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KPLKK	685		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)