Q13635: Protein patched homolog 1

General Information

Protein names	- Protein patched homolog 1 - PTC - PTC1
Gene names	PTCH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13635

4 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform L' of Protein patched homolog 1 - Isoform M of Protein patched homolog 1 - Isoform S of Protein patched homolog 1

Sequence View

        10         20         30         40         50         60
MASAGNAAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL HRPSYCDAAF
        70         80         90        100        110        120
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN
       130        140        150        160        170        180
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALLQHLD
       190        200        210        220        230        240
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK
       250        260        270        280        290        300
LQSGTAYLLG KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA
       310        320        330        340        350        360
DPDCPATAPN KNSTKPLDMA LVLNGGCHGL SRKYMHWQEE LIVGGTVKNS TGKLVSAHAL
       370        380        390        400        410        420
QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ RTYVEVVHQS VAQNSTQKVL
       430        440        450        460        470        480
SFTTTTLDDI LKSFSDVSVI RVASGYLLML AYACLTMLRW DCSKSQGAVG LAGVLLVALS
       490        500        510        520        530        540
VAAGLGLCSL IGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC
       550        560        570        580        590        600
LKRTGASVAL TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL
       610        620        630        640        650        660
YRREDRRLDI FCCFTSPCVS RVIQVEPQAY TDTHDNTRYS PPPPYSSHSF AHETQITMQS
       670        680        690        700        710        720
TVQLRTEYDP HTHVYYTTAE PRSEISVQPV TVTQDTLSCQ SPESTSSTRD LLSQFSDSSL
       730        740        750        760        770        780
HCLEPPCTKW TLSSFAEKHY APFLLKPKAK VVVIFLFLGL LGVSLYGTTR VRDGLDLTDI
       790        800        810        820        830        840
VPRETREYDF IAAQFKYFSF YNMYIVTQKA DYPNIQHLLY DLHRSFSNVK YVMLEENKQL
       850        860        870        880        890        900
PKMWLHYFRD WLQGLQDAFD SDWETGKIMP NNYKNGSDDG VLAYKLLVQT GSRDKPIDIS
       910        920        930        940        950        960
QLTKQRLVDA DGIINPSAFY IYLTAWVSND PVAYAASQAN IRPHRPEWVH DKADYMPETR
       970        980        990       1000       1010       1020
LRIPAAEPIE YAQFPFYLNG LRDTSDFVEA IEKVRTICSN YTSLGLSSYP NGYPFLFWEQ
      1030       1040       1050       1060       1070       1080
YIGLRHWLLL FISVVLACTF LVCAVFLLNP WTAGIIVMVL ALMTVELFGM MGLIGIKLSA
      1090       1100       1110       1120       1130       1140
VPVVILIASV GIGVEFTVHV ALAFLTAIGD KNRRAVLALE HMFAPVLDGA VSTLLGVLML
      1150       1160       1170       1180       1190       1200
AGSEFDFIVR YFFAVLAILT ILGVLNGLVL LPVLLSFFGP YPEVSPANGL NRLPTPSPEP
      1210       1220       1230       1240       1250       1260
PPSVVRFAMP PGHTHSGSDS SDSEYSSQTT VSGLSEELRH YEAQQGAGGP AHQVIVEATE
      1270       1280       1290       1300       1310       1320
NPVFAHSTVV HPESRHHPPS NPRQQPHLDS GSLPPGRQGQ QPRRDPPREG LWPPPYRPRR
      1330       1340       1350       1360       1370       1380
DAFEISTEGH SGPSNRARWG PRGARSHNPR NPASTAMGSS VPGYCQPITT VTASASVTVA
      1390       1400       1410       1420       1430       1440
VHPPPVPGPG RNPRGGLCPG YPETDHGLFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER

PRGSSSN         10         20         30         40         50         60
MASAGNAAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL HRPSYCDAAF
        70         80         90        100        110        120
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN
       130        140        150        160        170        180
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALLQHLD
       190        200        210        220        230        240
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK
       250        260        270        280        290        300
LQSGTAYLLG KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA
       310        320        330        340        350        360
DPDCPATAPN KNSTKPLDMA LVLNGGCHGL SRKYMHWQEE LIVGGTVKNS TGKLVSAHAL
       370        380        390        400        410        420
QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ RTYVEVVHQS VAQNSTQKVL
       430        440        450        460        470        480
SFTTTTLDDI LKSFSDVSVI RVASGYLLML AYACLTMLRW DCSKSQGAVG LAGVLLVALS
       490        500        510        520        530        540
VAAGLGLCSL IGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC
       550        560        570        580        590        600
LKRTGASVAL TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL
       610        620        630        640        650        660
YRREDRRLDI FCCFTSPCVS RVIQVEPQAY TDTHDNTRYS PPPPYSSHSF AHETQITMQS
       670        680        690        700        710        720
TVQLRTEYDP HTHVYYTTAE PRSEISVQPV TVTQDTLSCQ SPESTSSTRD LLSQFSDSSL
       730        740        750        760        770        780
HCLEPPCTKW TLSSFAEKHY APFLLKPKAK VVVIFLFLGL LGVSLYGTTR VRDGLDLTDI
       790        800        810        820        830        840
VPRETREYDF IAAQFKYFSF YNMYIVTQKA DYPNIQHLLY DLHRSFSNVK YVMLEENKQL
       850        860        870        880        890        900
PKMWLHYFRD WLQGLQDAFD SDWETGKIMP NNYKNGSDDG VLAYKLLVQT GSRDKPIDIS
       910        920        930        940        950        960
QLTKQRLVDA DGIINPSAFY IYLTAWVSND PVAYAASQAN IRPHRPEWVH DKADYMPETR
       970        980        990       1000       1010       1020
LRIPAAEPIE YAQFPFYLNG LRDTSDFVEA IEKVRTICSN YTSLGLSSYP NGYPFLFWEQ
      1030       1040       1050       1060       1070       1080
YIGLRHWLLL FISVVLACTF LVCAVFLLNP WTAGIIVMVL ALMTVELFGM MGLIGIKLSA
      1090       1100       1110       1120       1130       1140
VPVVILIASV GIGVEFTVHV ALAFLTAIGD KNRRAVLALE HMFAPVLDGA VSTLLGVLML
      1150       1160       1170       1180       1190       1200
AGSEFDFIVR YFFAVLAILT ILGVLNGLVL LPVLLSFFGP YPEVSPANGL NRLPTPSPEP
      1210       1220       1230       1240       1250       1260
PPSVVRFAMP PGHTHSGSDS SDSEYSSQTT VSGLSEELRH YEAQQGAGGP AHQVIVEATE
      1270       1280       1290       1300       1310       1320
NPVFAHSTVV HPESRHHPPS NPRQQPHLDS GSLPPGRQGQ QPRRDPPREG LWPPPYRPRR
      1330       1340       1350       1360       1370       1380
DAFEISTEGH SGPSNRARWG PRGARSHNPR NPASTAMGSS VPGYCQPITT VTASASVTVA
      1390       1400       1410       1420       1430       1440
VHPPPVPGPG RNPRGGLCPG YPETDHGLFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER

PRGSSSN         10         20         30         40         50         60
MASAGNAAEP QDRGGGGSGC IGAPGRPAGG GRRRRTGGLR RAAAPDRDYL HRPSYCDAAF
        70         80         90        100        110        120
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN
       130        140        150        160        170        180
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALLQHLD
       190        200        210        220        230        240
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK
       250        260        270        280        290        300
LQSGTAYLLG KPPLRWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA
       310        320        330        340        350        360
DPDCPATAPN KNSTKPLDMA LVLNGGCHGL SRKYMHWQEE LIVGGTVKNS TGKLVSAHAL
       370        380        390        400        410        420
QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ RTYVEVVHQS VAQNSTQKVL
       430        440        450        460        470        480
SFTTTTLDDI LKSFSDVSVI RVASGYLLML AYACLTMLRW DCSKSQGAVG LAGVLLVALS
       490        500        510        520        530        540
VAAGLGLCSL IGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC
       550        560        570        580        590        600
LKRTGASVAL TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL
       610        620        630        640        650        660
YRREDRRLDI FCCFTSPCVS RVIQVEPQAY TDTHDNTRYS PPPPYSSHSF AHETQITMQS
       670        680        690        700        710        720
TVQLRTEYDP HTHVYYTTAE PRSEISVQPV TVTQDTLSCQ SPESTSSTRD LLSQFSDSSL
       730        740        750        760        770        780
HCLEPPCTKW TLSSFAEKHY APFLLKPKAK VVVIFLFLGL LGVSLYGTTR VRDGLDLTDI
       790        800        810        820        830        840
VPRETREYDF IAAQFKYFSF YNMYIVTQKA DYPNIQHLLY DLHRSFSNVK YVMLEENKQL
       850        860        870        880        890        900
PKMWLHYFRD WLQGLQDAFD SDWETGKIMP NNYKNGSDDG VLAYKLLVQT GSRDKPIDIS
       910        920        930        940        950        960
QLTKQRLVDA DGIINPSAFY IYLTAWVSND PVAYAASQAN IRPHRPEWVH DKADYMPETR
       970        980        990       1000       1010       1020
LRIPAAEPIE YAQFPFYLNG LRDTSDFVEA IEKVRTICSN YTSLGLSSYP NGYPFLFWEQ
      1030       1040       1050       1060       1070       1080
YIGLRHWLLL FISVVLACTF LVCAVFLLNP WTAGIIVMVL ALMTVELFGM MGLIGIKLSA
      1090       1100       1110       1120       1130       1140
VPVVILIASV GIGVEFTVHV ALAFLTAIGD KNRRAVLALE HMFAPVLDGA VSTLLGVLML
      1150       1160       1170       1180       1190       1200
AGSEFDFIVR YFFAVLAILT ILGVLNGLVL LPVLLSFFGP YPEVSPANGL NRLPTPSPEP
      1210       1220       1230       1240       1250       1260
PPSVVRFAMP PGHTHSGSDS SDSEYSSQTT VSGLSEELRH YEAQQGAGGP AHQVIVEATE
      1270       1280       1290       1300       1310       1320
NPVFAHSTVV HPESRHHPPS NPRQQPHLDS GSLPPGRQGQ QPRRDPPREG LWPPPYRPRR
      1330       1340       1350       1360       1370       1380
DAFEISTEGH SGPSNRARWG PRGARSHNPR NPASTAMGSS VPGYCQPITT VTASASVTVA
      1390       1400       1410       1420       1430       1440
VHPPPVPGPG RNPRGGLCPG YPETDHGLFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER

PRGSSSN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13635-1-unknown	MASAGN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13635-152-unknown	MFNPQL...	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86448
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414823
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447797
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447008
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447878
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448843
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450131
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399981
Q13635-152-unknown	MFNPQL...	152	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396135
Q13635-152-unknown	MFNPQL...	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105722
Q13635-152-unknown	MFNPQL...	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105723
Q13635-281-unknown	MLNKAE...	281	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449078
Q13635-281-unknown	MLNKAE...	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198700
Q13635-281-unknown	MLNKAE...	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198701
Q13635-281-unknown	MLNKAE...	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198702
Q13635-284-unknown	KAEVGH...	284	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000364420
Q13635-284-unknown	KAEVGH...	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198718
Q13635-284-unknown	KAEVGH...	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198719
Q13635-284-unknown	KAEVGH...	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198720

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKLQSG	243	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450131
...TAYLLG	249	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449745
...LVLNGG	325	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447797
...LVLNGG	325	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447008
...LVLNGG	325	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447878
...LVLNGG	325	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448843
...IVGGTV	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449078
...SEISVQ	687	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000364420
...GSSSN	1447	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GSSSN	1447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82066
...GSSSN	1447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82065
...GSSSN	1447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82064

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)