TopFIND 4.0

Q13950: Runt-related transcription factor 2

General Information

Protein names
- Runt-related transcription factor 2
- Acute myeloid leukemia 3 protein
- Core-binding factor subunit alpha-1
- CBF-alpha-1
- Oncogene AML-3
- Osteoblast-specific transcription factor 2
- OSF-2
- Polyomavirus enhancer-binding protein 2 alpha A subunit
- PEA2-alpha A
- PEBP2-alpha A
- SL3-3 enhancer factor 1 alpha A subunit
- SL3/AKV core-binding factor alpha A subunit
Gene names RUNX2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q13950

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 
        70         80         90        100        110        120 
QQQQQQQQQQ QEAAAAAAAA AAAAAAAAAV PRLRPPHDNR TMVEIIADHP AELVRTDSPN 
       130        140        150        160        170        180 
FLCSVLPSHW RCNKTLPVAF KVVALGEVPD GTVVTVMAGN DENYSAELRN ASAVMKNQVA 
       190        200        210        220        230        240 
RFNDLRFVGR SGRGKSFTLT ITVFTNPPQV ATYHRAIKVT VDGPREPRRH RQKLDDSKPS 
       250        260        270        280        290        300 
LFSDRLSDLG RIPHPSMRVG VPPQNPRPSL NSAPSPFNPQ GQSQITDPRQ AQSSPPWSYD 
       310        320        330        340        350        360 
QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS DDDTATSDFC LWPSTLSKKS 
       370        380        390        400        410        420 
QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY TPPVTSGMSL GMSATTHYHT 
       430        440        450        460        470        480 
YLPPPYPGSS QSQSGPFQTS STPYLYYGTS SGSYQFPMVP GGDRSPSRML PPCTTTSNGS 
       490        500        510        520    
TLLNPNLPNQ NDGVDADGSH SSSPTVLNSS GRMDESVWRP Y

Isoforms

- Isoform 2 of Runt-related transcription factor 2 - Isoform 3 of Runt-related transcription factor 2

Sequence View

        10         20         30         40         50         60 
MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 
        70         80         90        100        110        120 
QQQQQQQQQQ QEAAAAAAAA AAAAAAAAAV PRLRPPHDNR TMVEIIADHP AELVRTDSPN 
       130        140        150        160        170        180 
FLCSVLPSHW RCNKTLPVAF KVVALGEVPD GTVVTVMAGN DENYSAELRN ASAVMKNQVA 
       190        200        210        220        230        240 
RFNDLRFVGR SGRGKSFTLT ITVFTNPPQV ATYHRAIKVT VDGPREPRRH RQKLDDSKPS 
       250        260        270        280        290        300 
LFSDRLSDLG RIPHPSMRVG VPPQNPRPSL NSAPSPFNPQ GQSQITDPRQ AQSSPPWSYD 
       310        320        330        340        350        360 
QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS DDDTATSDFC LWPSTLSKKS 
       370        380        390        400        410        420 
QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY TPPVTSGMSL GMSATTHYHT 
       430        440        450        460        470        480 
YLPPPYPGSS QSQSGPFQTS STPYLYYGTS SGSYQFPMVP GGDRSPSRML PPCTTTSNGS 
       490        500        510        520    
TLLNPNLPNQ NDGVDADGSH SSSPTVLNSS GRMDESVWRP Y         10         20         30         40         50         60 
MASNSLFSTV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS DVSPVVAAQQ QQQQQQQQQQ 
        70         80         90        100        110        120 
QQQQQQQQQQ QEAAAAAAAA AAAAAAAAAV PRLRPPHDNR TMVEIIADHP AELVRTDSPN 
       130        140        150        160        170        180 
FLCSVLPSHW RCNKTLPVAF KVVALGEVPD GTVVTVMAGN DENYSAELRN ASAVMKNQVA 
       190        200        210        220        230        240 
RFNDLRFVGR SGRGKSFTLT ITVFTNPPQV ATYHRAIKVT VDGPREPRRH RQKLDDSKPS 
       250        260        270        280        290        300 
LFSDRLSDLG RIPHPSMRVG VPPQNPRPSL NSAPSPFNPQ GQSQITDPRQ AQSSPPWSYD 
       310        320        330        340        350        360 
QSYPSYLSQM TSPSIHSTTP LSSTRGTGLP AITDVPRRIS DDDTATSDFC LWPSTLSKKS 
       370        380        390        400        410        420 
QAGASELGPF SDPRQFPSIS SLTESRFSNP RMHYPATFTY TPPVTSGMSL GMSATTHYHT 
       430        440        450        460        470        480 
YLPPPYPGSS QSQSGPFQTS STPYLYYGTS SGSYQFPMVP GGDRSPSRML PPCTTTSNGS 
       490        500        510        520    
TLLNPNLPNQ NDGVDADGSH SSSPTVLNSS GRMDESVWRP Y



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)