Q14145: Kelch-like ECH-associated protein 1

General Information

Protein names	- Kelch-like ECH-associated protein 1 - Cytosolic inhibitor of Nrf2 - INrf2 - Kelch-like protein 19
Gene names	KEAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14145

1 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT
        70         80         90        100        110        120
KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM
       130        140        150        160        170        180
EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD
       190        200        210        220        230        240
PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR
       250        260        270        280        290        300
CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY
       310        320        330        340        350        360
LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV
       370        380        390        400        410        420
PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV
       430        440        450        460        470        480
IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG
       490        500        510        520        530        540
TNRLNSAECY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE
       550        560        570        580        590        600
TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG
       610        620
RSGVGVAVTM EPCRKQIDQQ NCTC

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

1 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14145-1-unknown	MQPDPR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...YMHFGE	212	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465024
...HFGEVA	214	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465126
...SLTPNF	279	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468671
...QNCTC	624		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QNCTC	624		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QNCTC	624	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QNCTC	624		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...QNCTC	624		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)