Q14242: P-selectin glycoprotein ligand 1

General Information

Protein names	- P-selectin glycoprotein ligand 1 - PSGL-1 - Selectin P ligand - CD162
Gene names	SELPLG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14242

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP
        70         80         90        100        110        120
EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME
       130        140        150        160        170        180
IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE
       190        200        210        220        230        240
AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE
       250        260        270        280        290        300
AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA
       310        320        330        340        350        360
SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT
       370        380        390        400        410
EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP

Isoforms

- Isoform 2 of P-selectin glycoprotein ligand 1

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14242-18-unknown	LQLWDT...	18		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14242-18-unknown	LQLWDT...	18		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt112011
Q14242-42-Pyrrolidone carboxylic acid	QATEYE...	42	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14242-42-Pyrrolidone carboxylic acid	QATEYE...	42	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115468
Q14242-49-unknown	LDYDFL...	49		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4936
Q14242-49-unknown	LDYDFL...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140288
Q14242-304-unknown	SVNYPV...	304		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC500
Q14242-304-unknown	SVNYPV...	304		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150347
Q14242-367-unknown	SLLPDG...	367		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167642
Q14242-367-	SLLPDG...	367			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14242-373-unknown	GEGPSA...	373		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167644
Q14242-373-	GEGPSA...	373			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TEYEYL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4936
...TEYEYL	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123410
...AASNLS	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC500
...AASNLS	303	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133744
...HSFLP	412	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSFLP	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84829

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATG_HUMAN	48	YEYL.\|.LDYD	inferred from experiment	unknown	MEROPS	Berndt MC	Gardiner EE et al.:Regulation of P-selectin bindin... (S01.133)	11520793,
BACE1_HUMAN	303	SNLS.\|.SVNY	inferred from experiment	unknown	MEROPS	Seed B	Lichtenthaler SF et al.:The cell adhesion protein P-sel... (A01.004)	14507929,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)