TopFIND 4.0

Q14397: Glucokinase regulatory protein

General Information

Protein names
- Glucokinase regulatory protein
- GKRP
- Glucokinase regulator
Gene names GCKR
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q14397

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI 
        70         80         90        100        110        120 
FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 
       130        140        150        160        170        180 
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV 
       190        200        210        220        230        240 
GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ 
       250        260        270        280        290        300 
KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
       310        320        330        340        350        360 
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV 
       370        380        390        400        410        420 
RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ 
       430        440        450        460        470        480 
TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL 
       490        500        510        520        530        540 
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR 
       550        560        570        580        590        600 
AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
       610        620    
VRSALAGPGQ KRTADPLEIL EPDVQ

Isoforms

- Isoform 2 of Glucokinase regulatory protein

Sequence View

        10         20         30         40         50         60 
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI 
        70         80         90        100        110        120 
FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 
       130        140        150        160        170        180 
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV 
       190        200        210        220        230        240 
GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ 
       250        260        270        280        290        300 
KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
       310        320        330        340        350        360 
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV 
       370        380        390        400        410        420 
RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ 
       430        440        450        460        470        480 
TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL 
       490        500        510        520        530        540 
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR 
       550        560        570        580        590        600 
AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
       610        620    
VRSALAGPGQ KRTADPLEIL EPDVQ



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Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EPDVQ 625 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)