Q14457: Beclin-1

General Information

Protein names	- Beclin-1 - Coiled-coil myosin-like BCL2-interacting protein - Protein GT197 - Beclin-1-C 35 kDa {ECO:0000303\|PubMed:21364619} - Beclin-1-C 37 kDa {ECO:0000303\|PubMed:21364619}
Gene names	BECN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14457

2 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE
        70         80         90        100        110        120
ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG
       130        140        150        160        170        180
DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL
       190        200        210        220        230        240
QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ
       250        260        270        280        290        300
LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW
       310        320        330        340        350        360
NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF
       370        380        390        400        410        420
WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN
       430        440        450
SEEQWTKALK FMLTNLKWGL AWVSSQFYNK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14457-1-Acetylation	MEGSKT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14457-152-unknown	LNVTEN...	152		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468104

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FVCQRC	20	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467597
...GETQEE	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467937
...PVEWNE	301	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466766
...LKFQRY	327	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468461
...HAMVAF	371	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468700
...QFYNK	450	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)