Q14739: Delta(14)-sterol reductase
| Protein names | - Delta(14)-sterol reductase - Delta-14-SR - 1.3.1.70 {ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:9630650} - 3-beta-hydroxysterol Delta (14)-reductase {ECO:0000303|PubMed:16784888} - C-14 sterol reductase - C14SR - Integral nuclear envelope inner membrane protein {ECO:0000303|PubMed:10828963} - LMN2R - Lamin-B receptor {ECO:0000303|PubMed:8157662, ECO:0000303|PubMed:8157663} - Sterol C14-reductase |
|---|---|
| Gene names | LBR |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q14739 |
5
N-termini
3
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPSRKFADGE VVRGRWPGSS LYYEVEILSH DSTSQLYTVK YKDGTELELK ENDIKPLTSF
70 80 90 100 110 120
RQRKGGSTSS SPSRRRGSRS RSRSRSPGRP PKSARRSASA SHQADIKEAR REVEVKLTPL
130 140 150 160 170 180
ILKPFGNSIS RYNGEPEHIE RNDAPHKNTQ EKFSLSQESS YIATQYSLRP RREEVKLKEI
190 200 210 220 230 240
DSKEEKYVAK ELAVRTFEVT PIRAKDLEFG GVPGVFLIMF GLPVFLFLLL LMCKQKDPSL
250 260 270 280 290 300
LNFPPPLPAL YELWETRVFG VYLLWFLIQV LFYLLPIGKV VEGTPLIDGR RLKYRLNGFY
310 320 330 340 350 360
AFILTSAVIG TSLFQGVEFH YVYSHFLQFA LAATVFCVVL SVYLYMRSLK APRNDLSPAS
370 380 390 400 410 420
SGNAVYDFFI GRELNPRIGT FDLKYFCELR PGLIGWVVIN LVMLLAEMKI QDRAVPSLAM
430 440 450 460 470 480
ILVNSFQLLY VVDALWNEEA LLTTMDIIHD GFGFMLAFGD LVWVPFIYSF QAFYLVSHPN
490 500 510 520 530 540
EVSWPMASLI IVLKLCGYVI FRGANSQKNA FRKNPSDPKL AHLKTIHTST GKNLLVSGWW
550 560 570 580 590 600
GFVRHPNYLG DLIMALAWSL PCGFNHILPY FYIIYFTMLL VHREARDEYH CKKKYGVAWE
610
KYCQRVPYRI FPYIY
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q14739-1-unknown | MPSRKF... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q14739-97- | SASASH... | 97 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
| Q14739-97-unknown | SASASH... | 97 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
| Q14739-121-unknown | ILKPFG... | 121 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
| Q14739-121-unknown | ILKPFG... | 121 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
| Q14739-370-unknown | IGRELN... | 370 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000397817 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LELKEN | 51 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000416554 | |||
| ...FGGVPG | 213 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000388059 | |||
| ...FPYIY | 615 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|