Q14814: Myocyte-specific enhancer factor 2D

General Information

Protein names	- Myocyte-specific enhancer factor 2D
Gene names	MEF2D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14814

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform MEF2DA'B of Myocyte-specific enhancer factor 2D - Isoform MEF2D0B of Myocyte-specific enhancer factor 2D - Isoform MEF2DA0 of Myocyte-specific enhancer factor 2D - Isoform MEF2DA'0 of Myocyte-specific enhancer factor 2D - Isoform MEF2D00 of Myocyte-specific enhancer factor 2D

Sequence View

        10         20         30         40         50         60
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
       130        140        150        160        170        180
SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
       190        200        210        220        230        240
PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG
       250        260        270        280        290        300
NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV
       310        320        330        340        350        360
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN
       370        380        390        400        410        420
VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP
       430        440        450        460        470        480
LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET
       490        500        510        520
GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K         10         20         30         40         50         60
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
       130        140        150        160        170        180
SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
       190        200        210        220        230        240
PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG
       250        260        270        280        290        300
NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV
       310        320        330        340        350        360
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN
       370        380        390        400        410        420
VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP
       430        440        450        460        470        480
LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET
       490        500        510        520
GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K         10         20         30         40         50         60
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
       130        140        150        160        170        180
SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
       190        200        210        220        230        240
PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG
       250        260        270        280        290        300
NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV
       310        320        330        340        350        360
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN
       370        380        390        400        410        420
VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP
       430        440        450        460        470        480
LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET
       490        500        510        520
GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K         10         20         30         40         50         60
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
       130        140        150        160        170        180
SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
       190        200        210        220        230        240
PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG
       250        260        270        280        290        300
NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV
       310        320        330        340        350        360
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN
       370        380        390        400        410        420
VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP
       430        440        450        460        470        480
LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET
       490        500        510        520
GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K         10         20         30         40         50         60
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
        70         80         90        100        110        120
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
       130        140        150        160        170        180
SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
       190        200        210        220        230        240
PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG
       250        260        270        280        290        300
NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV
       310        320        330        340        350        360
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN
       370        380        390        400        410        420
VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP
       430        440        450        460        470        480
LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET
       490        500        510        520
GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14814-1-unknown	MGRKKI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14814-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80828
Q14814-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80829
Q14814-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80830
Q14814-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80831
Q14814-1-unknown	MGRKKI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80832
Q14814-289-unknown	HLDLNN...	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2958
Q14814-289-unknown	HLDLNN...	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148212
Q14814-289-unknown	HLDLNN...	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149548
Q14814-292-unknown	LNNAQR...	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2961
Q14814-292-unknown	LNNAQR...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148296
Q14814-292-unknown	LNNAQR...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149616
Q14814-292-unknown	LNNAQR...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198410
Q14814-292-unknown	LNNAQR...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198411
Q14814-292-unknown	LNNAQR...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198412

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HLTEDH	288	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2958
...HLTEDH	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131579
...HLTEDH	288	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132936
...EDHLDL	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2961
...EDHLDL	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131666
...EDHLDL	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133003
...TWTLK	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TWTLK	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76450
...TWTLK	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76447
...TWTLK	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76449
...TWTLK	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76448
...TWTLK	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76446

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	288	TEDH.\|.HLDL	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,
CASP7_HUMAN	291	HLDL.\|.LNNA	inferred from experiment	unknown	MEROPS	Lipton SA	Okamoto S et al.:Dominant-interfering forms of M... (C14.003)	11904443,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)