TopFIND 4.0

Q15465: Sonic hedgehog protein

General Information

Protein names
- Sonic hedgehog protein
- SHH
- HHG-1
- Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains {ECO:0000303|PubMed:24522195}
- ShhNC {ECO:0000303|PubMed:24522195}
- Sonic hedgehog protein N-product
- ShhN
- Shh N-terminal processed signaling domains {ECO:0000303|PubMed:24522195}
- ShhNp {ECO:0000303|PubMed:24522195}
Gene names SHH
Organism Homo sapiens
Protease Family
Protease ID C46.002
Chromosome location
UniProt ID Q15465

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLLLARCLLL VLVSSLLVCS GLACGPGRGF GKRRHPKKLT PLAYKQFIPN VAEKTLGASG 
        70         80         90        100        110        120 
RYEGKISRNS ERFKELTPNY NPDIIFKDEE NTGADRLMTQ RCKDKLNALA ISVMNQWPGV 
       130        140        150        160        170        180 
KLRVTEGWDE DGHHSEESLH YEGRAVDITT SDRDRSKYGM LARLAVEAGF DWVYYESKAH 
       190        200        210        220        230        240 
IHCSVKAENS VAAKSGGCFP GSATVHLEQG GTKLVKDLSP GDRVLAADDQ GRLLYSDFLT 
       250        260        270        280        290        300 
FLDRDDGAKK VFYVIETREP RERLLLTAAH LLFVAPHNDS ATGEPEASSG SGPPSGGALG 
       310        320        330        340        350        360 
PRALFASRVR PGQRVYVVAE RDGDRRLLPA AVHSVTLSEE AAGAYAPLTA QGTILINRVL 
       370        380        390        400        410        420 
ASCYAVIEEH SWAHRAFAPF RLAHALLAAL APARTDRGGD SGGGDRGGGG GRVALTAPGA 
       430        440        450        460    
ADAPGAGATA GIHWYSQLLY QIGTWLLDSE ALHPLGMAVK SS

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AKSGGC 197 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AVKSS 462 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)