Q15746: Myosin light chain kinase, smooth muscle

General Information

Protein names	- Myosin light chain kinase, smooth muscle - MLCK - smMLCK - 2.7.11.18 - Kinase-related protein - KRP - Telokin - Myosin light chain kinase, smooth muscle, deglutamylated form
Gene names	MYLK
Organism	Homo sapiens
Protease Family
Protease ID	I43.001
Chromosome location
UniProt ID	Q15746

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Myosin light chain kinase, smooth muscle - Isoform 3A of Myosin light chain kinase, smooth muscle - Isoform 3B of Myosin light chain kinase, smooth muscle - Isoform 4 of Myosin light chain kinase, smooth muscle - Isoform Del-1790 of Myosin light chain kinase, smooth muscle - Isoform 5 of Myosin light chain kinase, smooth muscle - Isoform 6 of Myosin light chain kinase, smooth muscle - Isoform 7 of Myosin light chain kinase, smooth muscle - Isoform 8 of Myosin light chain kinase, smooth muscle - Isoform 9 of Myosin light chain kinase, smooth muscle

Sequence View

        10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE         10         20         30         40         50         60
MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP
        70         80         90        100        110        120
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE
       130        140        150        160        170        180
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF
       190        200        210        220        230        240
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG
       250        260        270        280        290        300
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP
       310        320        330        340        350        360
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG
       370        380        390        400        410        420
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP
       430        440        450        460        470        480
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR
       490        500        510        520        530        540
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT
       550        560        570        580        590        600
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV
       610        620        630        640        650        660
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG
       670        680        690        700        710        720
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ
       730        740        750        760        770        780
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV
       790        800        810        820        830        840
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG
       850        860        870        880        890        900
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL
       910        920        930        940        950        960
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK
       970        980        990       1000       1010       1020
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS
      1030       1040       1050       1060       1070       1080
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG
      1090       1100       1110       1120       1130       1140
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT
      1150       1160       1170       1180       1190       1200
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE
      1210       1220       1230       1240       1250       1260
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK
      1270       1280       1290       1300       1310       1320
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ
      1330       1340       1350       1360       1370       1380
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE
      1390       1400       1410       1420       1430       1440
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD
      1450       1460       1470       1480       1490       1500
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA
      1510       1520       1530       1540       1550       1560
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER
      1570       1580       1590       1600       1610       1620
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV
      1630       1640       1650       1660       1670       1680
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF
      1690       1700       1710       1720       1730       1740
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM
      1750       1760       1770       1780       1790       1800
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV
      1810       1820       1830       1840       1850       1860
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD
      1870       1880       1890       1900       1910
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q15746-1-unknown	MGDVKL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q15746-1-unknown	MGDVKL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81981
Q15746-1-unknown	MGDVKL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81982
Q15746-1-unknown	MGDVKL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81983
Q15746-1-unknown	MGDVKL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81984
Q15746-1-unknown	MGDVKL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81985
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81986
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99566
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99568
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99564
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99565
Q15746-923-unknown	MDFRAN...	923	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99567
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81988
Q15746-1201-unknown	MKSRRP...	1201	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422984
Q15746-1201-unknown	MKSRRP...	1201	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000346846
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99689
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99692
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99694
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99690
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99691
Q15746-1201-unknown	MKSRRP...	1201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99693
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81987
Q15746-1761-unknown	MAMISG...	1761	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428967
Q15746-1761-unknown	MAMISG...	1761	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463691
Q15746-1761-unknown	MAMISG...	1761	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462118
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99625
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99626
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99629
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99628
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99631
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99630
Q15746-1761-unknown	MAMISG...	1761	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99627
Q15746-1761-unknown	MAMISG...	1761	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q15746-1761-unknown	MAMISG...	1761	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GEKPEE	1429	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422984
...EGEGEE	1910	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93800
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93799
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93801
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93804
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93803
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93806
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93805
...EGEGEE	1910	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93802
...EEEEE	1914	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77605
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77606
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77604
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77601
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77602
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77599
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77600
...EEEEE	1914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77603

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)