Q15797: Mothers against decapentaplegic homolog 1

General Information

Protein names	- Mothers against decapentaplegic homolog 1 - MAD homolog 1 - Mothers against DPP homolog 1 - JV4-1 - Mad-related protein 1 - SMAD family member 1 - SMAD 1 - Smad1 - hSMAD1 - Transforming growth factor-beta-signaling protein 1 - BSP-1
Gene names	SMAD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15797

2 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ
        70         80         90        100        110        120
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV
       130        140        150        160        170        180
CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN
       190        200        210        220        230        240
SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ
       250        260        270        280        290        300
PMDTNMMAPP LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
       310        320        330        340        350        360
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC
       370        380        390        400        410        420
NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW
       430        440        450        460
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS

Isoforms

- Isoform 2 of Mothers against decapentaplegic homolog 1

Sequence View

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15797-1-Acetylation	MNVTSL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15797-1-Acetylation	MNVTSL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15797-238-	GSQPMD...	238			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALSCPG	58	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422706
...VWRWPD	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424649
...ELKPLE	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424959
...CCEFPF	112	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425270
...RVESPV	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427002
...ISSVS	465	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)