Q16236: Nuclear factor erythroid 2-related factor 2

General Information

Protein names	- Nuclear factor erythroid 2-related factor 2 - NF-E2-related factor 2 - NFE2-related factor 2 - HEBP1 - Nuclear factor, erythroid derived 2, like 2
Gene names	NFE2L2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16236

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear factor erythroid 2-related factor 2 - Isoform 3 of Nuclear factor erythroid 2-related factor 2

Sequence View

        10         20         30         40         50         60
MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE
        70         80         90        100        110        120
QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM
       130        140        150        160        170        180
QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM
       190        200        210        220        230        240
QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG
       250        260        270        280        290        300
NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP
       310        320        330        340        350        360
SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS
       370        380        390        400        410        420
VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA
       430        440        450        460        470        480
QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD
       490        500        510        520        530        540
FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL
       550        560        570        580        590        600
KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP

DVKKN         10         20         30         40         50         60
MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE
        70         80         90        100        110        120
QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM
       130        140        150        160        170        180
QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM
       190        200        210        220        230        240
QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG
       250        260        270        280        290        300
NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP
       310        320        330        340        350        360
SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS
       370        380        390        400        410        420
VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA
       430        440        450        460        470        480
QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD
       490        500        510        520        530        540
FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL
       550        560        570        580        590        600
KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP

DVKKN

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16236-1-unknown	MMDLEL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16236-17-unknown	MDLIDI...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82670
Q16236-17-unknown	MDLIDI...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82671
Q16236-225-unknown	NYHFYS...	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2218
Q16236-225-unknown	NYHFYS...	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146635
Q16236-225-unknown	NYHFYS...	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146899
Q16236-383-unknown	SAPGSV...	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2221
Q16236-383-unknown	SAPGSV...	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151175
Q16236-383-unknown	SAPGSV...	383	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151354

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTEVDN	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2218
...LTEVDN	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129944
...LTEVDN	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130230
...VEELDS	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2221
...VEELDS	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134577
...VEELDS	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134756
...DVKKN	605	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DVKKN	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78289
...DVKKN	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78288

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	224	EVDN.\|.NYHF	inferred from experiment	unknown	MEROPS	Tsujimoto Y	Ohtsubo T et al.:Identification of NRF2, a membe... (C14.003)	10510468,
CASP3_HUMAN	382	ELDS.\|.SAPG	inferred from experiment	unknown	MEROPS	Tsujimoto Y	Ohtsubo T et al.:Identification of NRF2, a membe... (C14.003)	10510468,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)