TopFIND 4.0

Q16518: Retinoid isomerohydrolase

General Information

Protein names
- Retinoid isomerohydrolase
- 3.1.1.64 {ECO:0000269|PubMed:25112876, ECO:0000269|PubMed:29659842}
- All-trans-retinyl-palmitate hydrolase
- Lutein isomerase
- Meso-zeaxanthin isomerase {ECO:0000303|PubMed:28874556}
- 5.3.3.22 {ECO:0000269|PubMed:28874556}
- Retinal pigment epithelium-specific 65 kDa protein
- Retinol isomerase
Gene names RPE65
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q16518

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSIQVEHPAG GYKKLFETVE ELSSPLTAHV TGRIPLWLTG SLLRCGPGLF EVGSEPFYHL 
        70         80         90        100        110        120 
FDGQALLHKF DFKEGHVTYH RRFIRTDAYV RAMTEKRIVI TEFGTCAFPD PCKNIFSRFF 
       130        140        150        160        170        180 
SYFRGVEVTD NALVNVYPVG EDYYACTETN FITKINPETL ETIKQVDLCN YVSVNGATAH 
       190        200        210        220        230        240 
PHIENDGTVY NIGNCFGKNF SIAYNIVKIP PLQADKEDPI SKSEIVVQFP CSDRFKPSYV 
       250        260        270        280        290        300 
HSFGLTPNYI VFVETPVKIN LFKFLSSWSL WGANYMDCFE SNETMGVWLH IADKKRKKYL 
       310        320        330        340        350        360 
NNKYRTSPFN LFHHINTYED NGFLIVDLCC WKGFEFVYNY LYLANLRENW EEVKKNARKA 
       370        380        390        400        410        420 
PQPEVRRYVL PLNIDKADTG KNLVTLPNTT ATAILCSDET IWLEPEVLFS GPRQAFEFPQ 
       430        440        450        460        470        480 
INYQKYCGKP YTYAYGLGLN HFVPDRLCKL NVKTKETWVW QEPDSYPSEP IFVSHPDALE 
       490        500        510        520        530    
EDDGVVLSVV VSPGAGQKPA YLLILNAKDL SEVARAEVEI NIPVTFHGLF KKS

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFKKS 533 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)