Q16625: Occludin

General Information

Protein names	- Occludin
Gene names	OCLN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16625

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Occludin - Isoform 3 of Occludin - Isoform 4 of Occludin - Isoform 5 of Occludin - Isoform 6 of Occludin - Isoform 7 of Occludin

Sequence View

        10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT         10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT         10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT         10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT         10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT         10         20         30         40         50         60
MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS
        70         80         90        100        110        120
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY
       130        140        150        160        170        180
GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA
       190        200        210        220        230        240
ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD
       250        260        270        280        290        300
PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN
       310        320        330        340        350        360
VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV
       370        380        390        400        410        420
DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY
       430        440        450        460        470        480
PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE
       490        500        510        520
YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16625-1-unknown	MSSRPL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16625-1-unknown	MSSRPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83650
Q16625-1-unknown	MSSRPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83651
Q16625-1-unknown	MSSRPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83654
Q16625-1-unknown	MSSRPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83655
Q16625-227-unknown	LYVDQY...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24781
Q16625-227-unknown	LYVDQY...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147640
Q16625-252-unknown	MIIVAF...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83652
Q16625-252-unknown	MIIVAF...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106867
Q16625-321-unknown	SPMAYS...	321	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2245
Q16625-321-unknown	SPMAYS...	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140667
Q16625-321-unknown	SPMAYS...	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149059
Q16625-321-unknown	SPMAYS...	321	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150369
Q16625-323-unknown	MAYSSN...	323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83653
Q16625-323-unknown	MAYSSN...	323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106939
Q16625-323-unknown	MAYSSN...	323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106941
Q16625-323-unknown	MAYSSN...	323	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106940

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PAATGL	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24781
...PAATGL	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130994
...PAATGL	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130995
...VERVDS	320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2245
...VERVDS	320	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123802
...VERVDS	320	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132443
...VERVDS	320	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133766
...DRQKT	522	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DRQKT	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79271
...DRQKT	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79270
...DRQKT	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79268

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP7_HUMAN	226	ATGL.\|.LYVD	inferred from experiment	unknown	MEROPS	Gorodeski GI	Gorodeski GI et al.:Estrogen decrease in tight junc... (M10.008)	17038551,
CASP3_HUMAN	320	RVDS.\|.SPMA	inferred from experiment	unknown	MEROPS	Huber O	Bojarski C et al.:The specific fates of tight jun... (C14.003)	15054114,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)