Q16850: Lanosterol 14-alpha demethylase

General Information

Protein names	- Lanosterol 14-alpha demethylase - LDM - 1.14.14.154 {ECO:0000269\|PubMed:20149798, ECO:0000269\|PubMed:8619637} - CYPLI - Cytochrome P450 51A1 - Cytochrome P450-14DM - Cytochrome P45014DM - Cytochrome P450LI - Sterol 14-alpha demethylase
Gene names	CYP51A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16850

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLLGLLQAG GSVLGQAMEK VTGGNLLSML LIACAFTLSL VYLIRLAAGH LVQLPAGVKS
        70         80         90        100        110        120
PPYIFSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS
       130        140        150        160        170        180
KNEDLNAEDV YSRLTTPVFG KGVAYDVPNP VFLEQKKMLK SGLNIAHFKQ HVSIIEKETK
       190        200        210        220        230        240
EYFESWGESG EKNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL
       250        260        270        280        290        300
LPGWLPLPSF RRRDRAHREI KDIFYKAIQK RRQSQEKIDD ILQTLLDATY KDGRPLTDDE
       310        320        330        340        350        360
VAGMLIGLLL AGQHTSSTTS AWMGFFLARD KTLQKKCYLE QKTVCGENLP PLTYDQLKDL
       370        380        390        400        410        420
NLLDRCIKET LRLRPPIMIM MRMARTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWVERLD
       430        440        450        460        470        480
FNPDRYLQDN PASGEKFAYV PFGAGRHRCI GENFAYVQIK TIWSTMLRLY EFDLIDGYFP
       490        500
TVNYTTMIHT PENPVIRYKR RSK

Isoforms

- Isoform 2 of Lanosterol 14-alpha demethylase

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16850-1-unknown	MLLLGL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16850-100-unknown	MVGKTF...	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71537
Q16850-100-unknown	MVGKTF...	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406757

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AFGKSP	80	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412536
...KRRSK	503	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRRSK	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67155

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)