Q16877: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

General Information

Protein names	- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 - 6PF-2-K/Fru-2,6-P2ase 4 - PFK/FBPase 4 - 6PF-2-K/Fru-2,6-P2ase testis-type isozyme - 6-phosphofructo-2-kinase - 2.7.1.105 - Fructose-2,6-bisphosphatase - 3.1.3.46
Gene names	PFKFB4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16877

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 - Isoform 3 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

Sequence View

        10         20         30         40         50         60
MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT
        70         80         90        100        110        120
RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE
       130        140        150        160        170        180
EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV
       190        200        210        220        230        240
NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY
       250        260        270        280        290        300
YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW
       310        320        330        340        350        360
TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDNYPLEFAL RDQDKYRYRY
       370        380        390        400        410        420
PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA YFLDKAAEQL PYLKCPLHTV
       430        440        450        460
LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ NVDISRPPEE ALVTVPAHQ         10         20         30         40         50         60
MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT
        70         80         90        100        110        120
RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE
       130        140        150        160        170        180
EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV
       190        200        210        220        230        240
NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY
       250        260        270        280        290        300
YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW
       310        320        330        340        350        360
TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDNYPLEFAL RDQDKYRYRY
       370        380        390        400        410        420
PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA YFLDKAAEQL PYLKCPLHTV
       430        440        450        460
LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ NVDISRPPEE ALVTVPAHQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16877-1-unknown	MASPRE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16877-35-unknown	MTNCPT...	35	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393047
Q16877-35-unknown	MTNCPT...	35	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437446

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGHVAV	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415764
...LDEDLD	209	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393047
...NEIDAG	329	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407657
...VPAHQ	469	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)