Q1HFZ0: tRNA (cytosine(34)-C(5))-methyltransferase

General Information

Protein names	- tRNA (cytosine(34)-C(5))-methyltransferase - 2.1.1.203 - Myc-induced SUN domain-containing protein - Misu - NOL1/NOP2/Sun domain family member 2
Gene names	Nsun2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q1HFZ0

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRRARGRRF QQPPQPEGEE DASDGGRKRG QAGWEGGYPE IVKENKLFEH YYQELKIVPE
        70         80         90        100        110        120
GEWDQFMESL REPLPATLRI TGYKSHAKEI LHCLKNKYFK ELEDLEVDGQ KVEVPQPLSW
       130        140        150        160        170        180
YPEELAWHTN LSRKILRKSP LLAKFHQFLV SETESGNISR QEAVSMIPPL LLNVEPHHKI
       190        200        210        220        230        240
LDMCAAPGSK TTQLIEMLHA DMSVPFPEGF VIANDVDNKR CYLLVHQAKR LSSPCIMVVN
       250        260        270        280        290        300
HDASSIPRLT VDVDGRKEIL FYDRILCDVP CSGDGTMRKN IDVWKKWTTL NSLQLHGLQL
       310        320        330        340        350        360
RIATRGAEQL AEGGRMVYST CSLNPVEDEA VIAALLEKSE GALELADVSA ELPGLKWMPG
       370        380        390        400        410        420
VSQWKVMTRD GQWFADWHEV PQGRHTQIRP TMFPPTDLEK LQAMHLERCL RILPHHQNTG
       430        440        450        460        470        480
GFFVAVLVKK APMPWNKRQP KVQNKSAEAR EPRVSSHVAA TEGNPSDQSE LESQMITGAG
       490        500        510        520        530        540
DSETAHNTEN TESNEKKDGV CGPPPSKKMK LFGFKEDPFV FIPEDDPLFP PIEKFYALDP
       550        560        570        580        590        600
SFPRMNLLTR TTEGKKRQLY MVSKELRNVL LNNSEKMKVI NTGIKVWCRN NSGEEFDCAF
       610        620        630        640        650        660
RLAQEGIYTL YPFINSRIIT VSMEDVKTLL TQENPFFRKL SSEAYSQVKD LAKGSVVLKY
       670        680        690        700        710        720
EPDSANPDTL QCPIVLCGWR GKASIRTFVP KNERLHYLRM MGLEVLGEKK KEGVILTNEN
       730        740        750
AASPEQPGDE DAKQTAQDPC VPDSVPGCDA AAAEPSR

Isoforms

- Isoform 2 of tRNA (cytosine(34)-C(5))-methyltransferase

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q1HFZ0-1-unknown	MGRRAR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q1HFZ0-67-unknown	MESLRE...	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83387
Q1HFZ0-71-unknown	REPLPA...	71	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q1HFZ0-71-unknown	REPLPA...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196493
Q1HFZ0-149-unknown	LVSETE...	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30409
Q1HFZ0-149-unknown	LVSETE...	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141489
Q1HFZ0-150-unknown	VSETES...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30411
Q1HFZ0-150-unknown	VSETES...	150	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141535
Q1HFZ0-211-unknown	VIANDV...	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30413
Q1HFZ0-211-unknown	VIANDV...	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144543
Q1HFZ0-250-unknown	TVDVDG...	250	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q1HFZ0-250-unknown	TVDVDG...	250	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198453

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KFHQFL	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30409
...KFHQFL	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124665
...FHQFLV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30411
...FHQFLV	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124712
...FPEGFV	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30413
...FPEGFV	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127810
...AEPSR	757	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AEPSR	757	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79005

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	148	HQFL.\|.LVSE	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> NSUN2_MOUSE @148
CATE_MOUSE	149	QFLV.\|.VSET	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> NSUN2_MOUSE @149
CATE_MOUSE	210	EGFV.\|.VIAN	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> NSUN2_MOUSE @210

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)