Q3LXA3: Triokinase/FMN cyclase {ECO:0000312|HGNC:HGNC:24552}

General Information

Protein names	- Triokinase/FMN cyclase {ECO:0000312\|HGNC:HGNC:24552} - Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) - ATP-dependent dihydroxyacetone kinase - DHA kinase - 2.7.1.28 - 2.7.1.29 - Glycerone kinase - Triokinase - Triose kinase - FAD-AMP lyase (cyclizing) - 4.6.1.15 - FAD-AMP lyase (cyclic FMN forming) - FMN cyclase
Gene names	DAK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q3LXA3

5 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTSKKLVNSV AGCADDALAG LVACNPNLQL LQGHRVALRS DLDSLKGRVA LLSGGGSGHE
        70         80         90        100        110        120
PAHAGFIGKG MLTGVIAGAV FTSPAVGSIL AAIRAVAQAG TVGTLLIVKN YTGDRLNFGL
       130        140        150        160        170        180
AREQARAEGI PVEMVVIGDD SAFTVLKKAG RRGLCGTVLI HKVAGALAEA GVGLEEIAKQ
       190        200        210        220        230        240
VNVVAKAMGT LGVSLSSCSV PGSKPTFELS ADEVELGLGI HGEAGVRRIK MATADEIVKL
       250        260        270        280        290        300
MLDHMTNTTN ASHVPVQPGS SVVMMVNNLG GLSFLELGII ADATVRSLEG RGVKIARALV
       310        320        330        340        350        360
GTFMSALEMP GISLTLLLVD EPLLKLIDAE TTAAAWPNVA AVSITGRKRS RVAPAEPQEA
       370        380        390        400        410        420
PDSTAAGGSA SKRMALVLER VCSTLLGLEE HLNALDRAAG DGDCGTTHSR AARAIQEWLK
       430        440        450        460        470        480
EGPPPASPAQ LLSKLSVLLL EKMGGSSGAL YGLFLTAAAQ PLKAKTSLPA WSAAMDAGLE
       490        500        510        520        530        540
AMQKYGKAAP GDRTMLDSLW AAGQELQAWK SPGADLLQVL TKAVKSAEAA AEATKNMEAG
       550        560        570
AGRASYISSA RLEQPDPGAV AAAAILRAIL EVLQS

Isoforms

- Isoform 2 of Triokinase/FMN cyclase

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q3LXA3-1-unknown	MTSKKL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q3LXA3-2-unknown	TSKKLV...	2	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432539
Q3LXA3-350-unknown	SRVAPA...	350	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459382
Q3LXA3-363-	STAAGG...	363		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q3LXA3-363-	STAAGG...	363		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q3LXA3-363-	STAAGG...	363		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q3LXA3-363-	STAAGG...	363		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q3LXA3-363-unknown	STAAGG...	363		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SGGGSG	57	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434405
...VLIHKV	162	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431844
...EVLQS	575	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EVLQS	575		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EVLQS	575		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EVLQS	575		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EVLQS	575		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)