TopFIND 4.0

Q3U1N2: Sterol regulatory element-binding protein 2

General Information

Protein names
- Sterol regulatory element-binding protein 2
- SREBP-2
- Sterol regulatory element-binding transcription factor 2
- Processed sterol regulatory element-binding protein 2
Gene names Srebf2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q3U1N2

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MDESSELGVL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGGGSN 
        70         80         90        100        110        120 
GGSGNNSSGR GNNGGATDPA VQRSFSQVPL STFSPSAASP QAPALQVKVS PTPPRATPVL 
       130        140        150        160        170        180 
QPRPQPQPQP PAQLQQQTVM ITPTFSTAPQ TRIIQQPLIY QNAATSFQVL QPQVQSLVTS 
       190        200        210        220        230        240 
PQVQPVTIQQ QVQTVQAQRV LTQTANGTLQ TLAPATVQTV AAPQVQQVPV LVQPQIIKTD 
       250        260        270        280        290        300 
SLVLTTLKTD GSPVMAAVQN PALTALTAPI QTAALQVPTL VGSNGTILTT MPVMMGQEKV 
       310        320        330        340        350        360 
PIKQVPGGVK QLDPPKEGER RTTHNIIEKR YRSSINDKII ELKDLVMGTD AKMHKSGVLR 
       370        380        390        400        410        420 
KAIDYIKYLQ QVNHKLRQEN MVLKLANQKN KLLKGIDLGS LVDSDVDLKI DDFNQNVLLM 
       430        440        450        460        470        480 
SPPASDSGSQ AGFSPYSIDS EPGSPLLDDA KVKDEPDSPP VALGMVDRSR ILLCVLTFLG 
       490        500        510        520        530        540 
LSFNPLTSLL QWGGAHNTDQ HPYSGSGRSV LSLESGAGGW FDWMVPTLLL WLVNGVIVLS 
       550        560        570        580        590        600 
VFVKLLVHGE PVIRPHSRPS VTFWRHRKQA DLDLAKGDFA AAAANLQTCL SVLGRALPTS 
       610        620        630        640        650        660 
RLDLACSLSW NVIRYSLQKL RLVRWLLKKV FQRWRATPAT AAGFEDEAKS SARDAALAYH 
       670        680        690        700        710        720 
RLHQLHITGK LPAGSACSDV HMALCAVNLA ECAEEKILPS TLIEIHLTAA MGLKTRCGGK 
       730        740        750        760        770        780 
LGFLASYFLN RAQSLCGPEH STVPDSLRWL CHPLGQKFFM ERSWSIKSAA KESLYCAQRS 
       790        800        810        820        830        840 
PADPIAQVHQ AFCKNLLERA VESLVKPQAK KKAGDQEEES CEFSSALEYL KLLHSFVDSV 
       850        860        870        880        890        900 
GFVTSPFSSS SVLRSALGPD VICRWWTSAV TMAISWLQGD DAAVRSRFTE VERVPKALEV 
       910        920        930        940        950        960 
TESPLVKAVF YTCRAMHASL SGKADGQQNS FCHCERASGH LWSSLNVSGT TSDPSLNHVI 
       970        980        990       1000       1010       1020 
QLFTCDLLLS LRTALWQKQA SASQLLGETY HASGTELAGF QRDLGSLRRL AHSFRPAYRK 
      1030       1040       1050       1060       1070       1080 
VFLHEATVRL MAGASPTRTH QLLEHSLRRR PTQNTKHGEV DTWPGQRERA TAILLACRHL 
      1090       1100       1110       1120       1130    
PLSFLSSPGQ RAVLLAEAAR TLEKVGDRRS CSDCQQMIVK LGGGTAIAAS 

Isoforms

- Isoform 2 of Sterol regulatory element-binding protein 2

Sequence View

        10         20         30         40         50         60 
MDESSELGVL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGGGSN 
        70         80         90        100        110        120 
GGSGNNSSGR GNNGGATDPA VQRSFSQVPL STFSPSAASP QAPALQVKVS PTPPRATPVL 
       130        140        150        160        170        180 
QPRPQPQPQP PAQLQQQTVM ITPTFSTAPQ TRIIQQPLIY QNAATSFQVL QPQVQSLVTS 
       190        200        210        220        230        240 
PQVQPVTIQQ QVQTVQAQRV LTQTANGTLQ TLAPATVQTV AAPQVQQVPV LVQPQIIKTD 
       250        260        270        280        290        300 
SLVLTTLKTD GSPVMAAVQN PALTALTAPI QTAALQVPTL VGSNGTILTT MPVMMGQEKV 
       310        320        330        340        350        360 
PIKQVPGGVK QLDPPKEGER RTTHNIIEKR YRSSINDKII ELKDLVMGTD AKMHKSGVLR 
       370        380        390        400        410        420 
KAIDYIKYLQ QVNHKLRQEN MVLKLANQKN KLLKGIDLGS LVDSDVDLKI DDFNQNVLLM 
       430        440        450        460        470        480 
SPPASDSGSQ AGFSPYSIDS EPGSPLLDDA KVKDEPDSPP VALGMVDRSR ILLCVLTFLG 
       490        500        510        520        530        540 
LSFNPLTSLL QWGGAHNTDQ HPYSGSGRSV LSLESGAGGW FDWMVPTLLL WLVNGVIVLS 
       550        560        570        580        590        600 
VFVKLLVHGE PVIRPHSRPS VTFWRHRKQA DLDLAKGDFA AAAANLQTCL SVLGRALPTS 
       610        620        630        640        650        660 
RLDLACSLSW NVIRYSLQKL RLVRWLLKKV FQRWRATPAT AAGFEDEAKS SARDAALAYH 
       670        680        690        700        710        720 
RLHQLHITGK LPAGSACSDV HMALCAVNLA ECAEEKILPS TLIEIHLTAA MGLKTRCGGK 
       730        740        750        760        770        780 
LGFLASYFLN RAQSLCGPEH STVPDSLRWL CHPLGQKFFM ERSWSIKSAA KESLYCAQRS 
       790        800        810        820        830        840 
PADPIAQVHQ AFCKNLLERA VESLVKPQAK KKAGDQEEES CEFSSALEYL KLLHSFVDSV 
       850        860        870        880        890        900 
GFVTSPFSSS SVLRSALGPD VICRWWTSAV TMAISWLQGD DAAVRSRFTE VERVPKALEV 
       910        920        930        940        950        960 
TESPLVKAVF YTCRAMHASL SGKADGQQNS FCHCERASGH LWSSLNVSGT TSDPSLNHVI 
       970        980        990       1000       1010       1020 
QLFTCDLLLS LRTALWQKQA SASQLLGETY HASGTELAGF QRDLGSLRRL AHSFRPAYRK 
      1030       1040       1050       1060       1070       1080 
VFLHEATVRL MAGASPTRTH QLLEHSLRRR PTQNTKHGEV DTWPGQRERA TAILLACRHL 
      1090       1100       1110       1120       1130    
PLSFLSSPGQ RAVLLAEAAR TLEKVGDRRS CSDCQQMIVK LGGGTAIAAS 



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q3U1N2-1-unknown MDESSE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q3U1N2-1-unknown MDESSE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90617
    Q3U1N2-306-unknown PGGVKQ... 306 inferred from electronic annotation unknown TISdb inferred from TISdb
    Q3U1N2-306-unknown PGGVKQ... 306 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt198882

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)