Q3ULM6: SUMO-specific isopeptidase USPL1

General Information

Protein names	- SUMO-specific isopeptidase USPL1 - 3.4.22.- - Ubiquitin-specific peptidase-like protein 1
Gene names	Uspl1
Organism	Mus musculus
Protease Family
Protease ID	C98.001
Chromosome location
UniProt ID	Q3ULM6

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTDDSLKIGN GLPLVGPGTD VGISSLPMLG YLGKNYASAK VTTDGHCPAC RAKGKLSALK
        70         80         90        100        110        120
PYRISFQESV FLCEDLQCIY PLGSESLTNL ISPDSEDCPT PSKPQKRKRL ETNCRNSPLP
       130        140        150        160        170        180
VHSKKTRSHI VTDSEPIVNG KYNGEVCDDF SASFPDTSAH QDPASTAASV EQSEALEADD
       190        200        210        220        230        240
VVVAATEDPA TVSVTSELEM PAKSRCLPLC QTLCVQWKNT QALCWLDCIL SALVHLEVLR
       250        260        270        280        290        300
KTVLEACSRE ECVFGRLFEM YHQADELLHT HHLHGVTGED CKKLTSEIFT EIDTCLNKVR
       310        320        330        340        350        360
DEIFAKLQPK LRCTLGDMES PVFALPVLLK LEPHVESLFT YSFSWNFECS HCGHQYQNRC
       370        380        390        400        410        420
VKSLVTFTNI VPEWHPLNAA HFGPCNSCNS KSQIRKMVLE RASPILMLHF VEGLPRRDLQ
       430        440        450        460        470        480
HYAFHFEGSL YQVTSVIQYQ ANNHFITWFL DADGSWLECD DLKGPCAKRH VTCEVPASET
       490        500        510        520        530        540
HIVIWERKSQ VPIEEAACLP CMKPNVQPVS GEEQPTCPAL CSLAGTATSE PSVAHPTSMA
       550        560        570        580        590        600
GAPQTLPEIQ AVAHGDSVLS GAKGMVDSIL PSALEETIQE TASVSQVDSK DCLLEDKPVA
       610        620        630        640        650        660
GSAALVRVLA FQPQDSPGSS GSSLVSSLCE GKLVAPCVDS SFPSQAVSTD LQAVLSQAGD
       670        680        690        700        710        720
TVVPNPVTDA PVPVLVQELK SLATEKDSQT QLLPLKTEKL DPEQPGKSQA SNLRKRETTA
       730        740        750        760        770        780
SSKTVAARSA QNQPRKEDQK RAFVGSWVKG LLSRGGAFMP TCVLSQSRAV SDLQPSVKGA
       790        800        810        820        830        840
SNFDGFKTKS ISRRSKRMSR KAKHMEELSP RNSSPPLSWT AALTQAAENA TSALLREQEG
       850        860        870        880        890        900
SRPAPLRHRS PGNESAISPA SRGDAAEDQV HKLRLKLLKK LKAKKKKLAA LISSPHREPS
       910        920        930        940        950        960
LSDHSEPASH CGTPASDQSE PVSHCGSPND CESIEDLLKE LQHQIDLADS KSGCTSAPDA
       970        980        990       1000       1010       1020
TSNNSQSHEE ILAELLSPTA MSEPSESGEL ELRYLEMGDS TPAQAPSEFS VVSLNTCLKQ
      1030       1040       1050       1060       1070       1080
DHDYCSPEKG QREVDLHSVM DSACIRTLNL GSPMKTDIFD DFFSTSALNS LTNDTLDIPH

FDDSLFENC

Isoforms

- Isoform 2 of SUMO-specific isopeptidase USPL1 - Isoform 3 of SUMO-specific isopeptidase USPL1 - Isoform 4 of SUMO-specific isopeptidase USPL1

Sequence View

        10         20         30         40         50         60
MTDDSLKIGN GLPLVGPGTD VGISSLPMLG YLGKNYASAK VTTDGHCPAC RAKGKLSALK
        70         80         90        100        110        120
PYRISFQESV FLCEDLQCIY PLGSESLTNL ISPDSEDCPT PSKPQKRKRL ETNCRNSPLP
       130        140        150        160        170        180
VHSKKTRSHI VTDSEPIVNG KYNGEVCDDF SASFPDTSAH QDPASTAASV EQSEALEADD
       190        200        210        220        230        240
VVVAATEDPA TVSVTSELEM PAKSRCLPLC QTLCVQWKNT QALCWLDCIL SALVHLEVLR
       250        260        270        280        290        300
KTVLEACSRE ECVFGRLFEM YHQADELLHT HHLHGVTGED CKKLTSEIFT EIDTCLNKVR
       310        320        330        340        350        360
DEIFAKLQPK LRCTLGDMES PVFALPVLLK LEPHVESLFT YSFSWNFECS HCGHQYQNRC
       370        380        390        400        410        420
VKSLVTFTNI VPEWHPLNAA HFGPCNSCNS KSQIRKMVLE RASPILMLHF VEGLPRRDLQ
       430        440        450        460        470        480
HYAFHFEGSL YQVTSVIQYQ ANNHFITWFL DADGSWLECD DLKGPCAKRH VTCEVPASET
       490        500        510        520        530        540
HIVIWERKSQ VPIEEAACLP CMKPNVQPVS GEEQPTCPAL CSLAGTATSE PSVAHPTSMA
       550        560        570        580        590        600
GAPQTLPEIQ AVAHGDSVLS GAKGMVDSIL PSALEETIQE TASVSQVDSK DCLLEDKPVA
       610        620        630        640        650        660
GSAALVRVLA FQPQDSPGSS GSSLVSSLCE GKLVAPCVDS SFPSQAVSTD LQAVLSQAGD
       670        680        690        700        710        720
TVVPNPVTDA PVPVLVQELK SLATEKDSQT QLLPLKTEKL DPEQPGKSQA SNLRKRETTA
       730        740        750        760        770        780
SSKTVAARSA QNQPRKEDQK RAFVGSWVKG LLSRGGAFMP TCVLSQSRAV SDLQPSVKGA
       790        800        810        820        830        840
SNFDGFKTKS ISRRSKRMSR KAKHMEELSP RNSSPPLSWT AALTQAAENA TSALLREQEG
       850        860        870        880        890        900
SRPAPLRHRS PGNESAISPA SRGDAAEDQV HKLRLKLLKK LKAKKKKLAA LISSPHREPS
       910        920        930        940        950        960
LSDHSEPASH CGTPASDQSE PVSHCGSPND CESIEDLLKE LQHQIDLADS KSGCTSAPDA
       970        980        990       1000       1010       1020
TSNNSQSHEE ILAELLSPTA MSEPSESGEL ELRYLEMGDS TPAQAPSEFS VVSLNTCLKQ
      1030       1040       1050       1060       1070       1080
DHDYCSPEKG QREVDLHSVM DSACIRTLNL GSPMKTDIFD DFFSTSALNS LTNDTLDIPH

FDDSLFENC         10         20         30         40         50         60
MTDDSLKIGN GLPLVGPGTD VGISSLPMLG YLGKNYASAK VTTDGHCPAC RAKGKLSALK
        70         80         90        100        110        120
PYRISFQESV FLCEDLQCIY PLGSESLTNL ISPDSEDCPT PSKPQKRKRL ETNCRNSPLP
       130        140        150        160        170        180
VHSKKTRSHI VTDSEPIVNG KYNGEVCDDF SASFPDTSAH QDPASTAASV EQSEALEADD
       190        200        210        220        230        240
VVVAATEDPA TVSVTSELEM PAKSRCLPLC QTLCVQWKNT QALCWLDCIL SALVHLEVLR
       250        260        270        280        290        300
KTVLEACSRE ECVFGRLFEM YHQADELLHT HHLHGVTGED CKKLTSEIFT EIDTCLNKVR
       310        320        330        340        350        360
DEIFAKLQPK LRCTLGDMES PVFALPVLLK LEPHVESLFT YSFSWNFECS HCGHQYQNRC
       370        380        390        400        410        420
VKSLVTFTNI VPEWHPLNAA HFGPCNSCNS KSQIRKMVLE RASPILMLHF VEGLPRRDLQ
       430        440        450        460        470        480
HYAFHFEGSL YQVTSVIQYQ ANNHFITWFL DADGSWLECD DLKGPCAKRH VTCEVPASET
       490        500        510        520        530        540
HIVIWERKSQ VPIEEAACLP CMKPNVQPVS GEEQPTCPAL CSLAGTATSE PSVAHPTSMA
       550        560        570        580        590        600
GAPQTLPEIQ AVAHGDSVLS GAKGMVDSIL PSALEETIQE TASVSQVDSK DCLLEDKPVA
       610        620        630        640        650        660
GSAALVRVLA FQPQDSPGSS GSSLVSSLCE GKLVAPCVDS SFPSQAVSTD LQAVLSQAGD
       670        680        690        700        710        720
TVVPNPVTDA PVPVLVQELK SLATEKDSQT QLLPLKTEKL DPEQPGKSQA SNLRKRETTA
       730        740        750        760        770        780
SSKTVAARSA QNQPRKEDQK RAFVGSWVKG LLSRGGAFMP TCVLSQSRAV SDLQPSVKGA
       790        800        810        820        830        840
SNFDGFKTKS ISRRSKRMSR KAKHMEELSP RNSSPPLSWT AALTQAAENA TSALLREQEG
       850        860        870        880        890        900
SRPAPLRHRS PGNESAISPA SRGDAAEDQV HKLRLKLLKK LKAKKKKLAA LISSPHREPS
       910        920        930        940        950        960
LSDHSEPASH CGTPASDQSE PVSHCGSPND CESIEDLLKE LQHQIDLADS KSGCTSAPDA
       970        980        990       1000       1010       1020
TSNNSQSHEE ILAELLSPTA MSEPSESGEL ELRYLEMGDS TPAQAPSEFS VVSLNTCLKQ
      1030       1040       1050       1060       1070       1080
DHDYCSPEKG QREVDLHSVM DSACIRTLNL GSPMKTDIFD DFFSTSALNS LTNDTLDIPH

FDDSLFENC         10         20         30         40         50         60
MTDDSLKIGN GLPLVGPGTD VGISSLPMLG YLGKNYASAK VTTDGHCPAC RAKGKLSALK
        70         80         90        100        110        120
PYRISFQESV FLCEDLQCIY PLGSESLTNL ISPDSEDCPT PSKPQKRKRL ETNCRNSPLP
       130        140        150        160        170        180
VHSKKTRSHI VTDSEPIVNG KYNGEVCDDF SASFPDTSAH QDPASTAASV EQSEALEADD
       190        200        210        220        230        240
VVVAATEDPA TVSVTSELEM PAKSRCLPLC QTLCVQWKNT QALCWLDCIL SALVHLEVLR
       250        260        270        280        290        300
KTVLEACSRE ECVFGRLFEM YHQADELLHT HHLHGVTGED CKKLTSEIFT EIDTCLNKVR
       310        320        330        340        350        360
DEIFAKLQPK LRCTLGDMES PVFALPVLLK LEPHVESLFT YSFSWNFECS HCGHQYQNRC
       370        380        390        400        410        420
VKSLVTFTNI VPEWHPLNAA HFGPCNSCNS KSQIRKMVLE RASPILMLHF VEGLPRRDLQ
       430        440        450        460        470        480
HYAFHFEGSL YQVTSVIQYQ ANNHFITWFL DADGSWLECD DLKGPCAKRH VTCEVPASET
       490        500        510        520        530        540
HIVIWERKSQ VPIEEAACLP CMKPNVQPVS GEEQPTCPAL CSLAGTATSE PSVAHPTSMA
       550        560        570        580        590        600
GAPQTLPEIQ AVAHGDSVLS GAKGMVDSIL PSALEETIQE TASVSQVDSK DCLLEDKPVA
       610        620        630        640        650        660
GSAALVRVLA FQPQDSPGSS GSSLVSSLCE GKLVAPCVDS SFPSQAVSTD LQAVLSQAGD
       670        680        690        700        710        720
TVVPNPVTDA PVPVLVQELK SLATEKDSQT QLLPLKTEKL DPEQPGKSQA SNLRKRETTA
       730        740        750        760        770        780
SSKTVAARSA QNQPRKEDQK RAFVGSWVKG LLSRGGAFMP TCVLSQSRAV SDLQPSVKGA
       790        800        810        820        830        840
SNFDGFKTKS ISRRSKRMSR KAKHMEELSP RNSSPPLSWT AALTQAAENA TSALLREQEG
       850        860        870        880        890        900
SRPAPLRHRS PGNESAISPA SRGDAAEDQV HKLRLKLLKK LKAKKKKLAA LISSPHREPS
       910        920        930        940        950        960
LSDHSEPASH CGTPASDQSE PVSHCGSPND CESIEDLLKE LQHQIDLADS KSGCTSAPDA
       970        980        990       1000       1010       1020
TSNNSQSHEE ILAELLSPTA MSEPSESGEL ELRYLEMGDS TPAQAPSEFS VVSLNTCLKQ
      1030       1040       1050       1060       1070       1080
DHDYCSPEKG QREVDLHSVM DSACIRTLNL GSPMKTDIFD DFFSTSALNS LTNDTLDIPH

FDDSLFENC

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q3ULM6-1-unknown	MTDDSL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q3ULM6-1-unknown	MTDDSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94004
Q3ULM6-200-unknown	MPAKSR...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94002
Q3ULM6-200-unknown	MPAKSR...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt94003
Q3ULM6-200-unknown	MPAKSR...	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000113894
Q3ULM6-200-unknown	MPAKSR...	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117221
Q3ULM6-200-unknown	MPAKSR...	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000113176
Q3ULM6-200-unknown	MPAKSR...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98666

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HLEVLR	239	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117221
...LFENC	1089	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFENC	1089	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89620

TopFIND

Q3ULM6: SUMO-specific isopeptidase USPL1

General Information

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates