Q4JK59: Methylcytosine dioxygenase TET2
| Protein names | - Methylcytosine dioxygenase TET2 - 1.14.11.n2 {ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:21817016} - Protein Ayu17-449 |
|---|---|
| Gene names | Tet2 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q4JK59 |
3
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MEQDRTTHAE GTRLSPFLIA PPSPISHTEP LAVKLQNGSP LAERPHPEVN GDTKWQSSQS
70 80 90 100 110 120
CYGISHMKGS QSSHESPHED RGYSRCLQNG GIKRTVSEPS LSGLHPNKIL KLDQKAKGES
130 140 150 160 170 180
NIFEESQERN HGKSSRQPNV SGLSDNGEPV TSTTQESSGA DAFPTRNYNG VEIQVLNEQE
190 200 210 220 230 240
GEKGRSVTLL KNKIVLMPNG ATVSAHSEEN TRGELLEKTQ CYPDCVSIAV QSTASHVNTP
250 260 270 280 290 300
SSQAAIELSH EIPQPSLTSA QINFSQTSSL QLPPEPAAMV TKACDADNAS KPAIVPGTCP
310 320 330 340 350 360
FQKAEHQQKS ALDIGPSRAE NKTIQGSMEL FAEEYYPSSD RNLQASHGSS EQYSKQKETN
370 380 390 400 410 420
GAYFRQSSKF PKDSISPTTV TPPSQSLLAP RLVLQPPLEG KGALNDVALE EHHDYPNRSN
430 440 450 460 470 480
RTLLREGKID HQPKTSSSQS LNPSVHTPNP PLMLPEQHQN DCGSPSPEKS RKMSEYLMYY
490 500 510 520 530 540
LPNHGHSGGL QEHSQYLMGH REQEIPKDAN GKQTQGSVQA APGWIELKAP NLHEALHQTK
550 560 570 580 590 600
RKDISLHSVL HSQTGPVNQM SSKQSTGNVN MPGGFQRLPY LQKTAQPEQK AQMYQVQVNQ
610 620 630 640 650 660
GPSPGMGDQH LQFQKALYQE CIPRTDPSSE AHPQAPSVPQ YHFQQRVNPS SDKHLSQQAT
670 680 690 700 710 720
ETQRLSGFLQ HTPQTQASQT PASQNSNFPQ ICQQQQQQQL QRKNKEQMPQ TFSHLQGSND
730 740 750 760 770 780
KQREGSCFGQ IKVEESFCVG NQYSKSSNFQ THNNTQGGLE QVQNINKNFP YSKILTPNSS
790 800 810 820 830 840
NLQILPSNDT HPACEREQAL HPVGSKTSNL QNMQYFPNNV TPNQDVHRCF QEQAQKPQQA
850 860 870 880 890 900
SSLQGLKDRS QGESPAPPAE AAQQRYLVHN EAKALPVPEQ GGSQTQTPPQ KDTQKHAALR
910 920 930 940 950 960
WLLLQKQEQQ QTQQSQPGHN QMLRPIKTEP VSKPSSYRYP LSPPQENMSS RIKQEISSPS
970 980 990 1000 1010 1020
RDNGQPKSII ETMEQHLKQF QLKSLCDYKA LTLKSQKHVK VPTDIQAAES ENHARAAEPQ
1030 1040 1050 1060 1070 1080
ATKSTDCSVL DDVSESDTPG EQSQNGKCEG CNPDKDEAPY YTHLGAGPDV AAIRTLMEER
1090 1100 1110 1120 1130 1140
YGEKGKAIRI EKVIYTGKEG KSSQGCPIAK WVYRRSSEEE KLLCLVRVRP NHTCETAVMV
1150 1160 1170 1180 1190 1200
IAIMLWDGIP KLLASELYSE LTDILGKCGI CTNRRCSQNE TRNCCCQGEN PETCGASFSF
1210 1220 1230 1240 1250 1260
GCSWSMYYNG CKFARSKKPR KFRLHGAEPK EEERLGSHLQ NLATVIAPIY KKLAPDAYNN
1270 1280 1290 1300 1310 1320
QVEFEHQAPD CCLGLKEGRP FSGVTACLDF SAHSHRDQQN MPNGSTVVVT LNREDNREVG
1330 1340 1350 1360 1370 1380
AKPEDEQFHV LPMYIIAPED EFGSTEGQEK KIRMGSIEVL QSFRRRRVIR IGELPKSCKK
1390 1400 1410 1420 1430 1440
KAEPKKAKTK KAARKRSSLE NCSSRTEKGK SSSHTKLMEN ASHMKQMTAQ PQLSGPVIRQ
1450 1460 1470 1480 1490 1500
PPTLQRHLQQ GQRPQQPQPP QPQPQTTPQP QPQPQHIMPG NSQSVGSHCS GSTSVYTRQP
1510 1520 1530 1540 1550 1560
TPHSPYPSSA HTSDIYGDTN HVNFYPTSSH ASGSYLNPSN YMNPYLGLLN QNNQYAPFPY
1570 1580 1590 1600 1610 1620
NGSVPVDNGS PFLGSYSPQA QSRDLHRYPN QDHLTNQNLP PIHTLHQQTF GDSPSKYLSY
1630 1640 1650 1660 1670 1680
GNQNMQRDAF TTNSTLKPNV HHLATFSPYP TPKMDSHFMG AASRSPYSHP HTDYKTSEHH
1690 1700 1710 1720 1730 1740
LPSHTIYSYT AAASGSSSSH AFHNKENDNI ANGLSRVLPG FNHDRTASAQ ELLYSLTGSS
1750 1760 1770 1780 1790 1800
QEKQPEVSGQ DAAAVQEIEY WSDSEHNFQD PCIGGVAIAP THGSILIECA KCEVHATTKV
1810 1820 1830 1840 1850 1860
NDPDRNHPTR ISLVLYRHKN LFLPKHCLAL WEAKMAEKAR KEEECGKNGS DHVSQKNHGK
1870 1880 1890 1900 1910
QEKREPTGPQ EPSYLRFIQS LAENTGSVTT DSTVTTSPYA FTQVTGPYNT FV
Isoforms
- Isoform 2 of Methylcytosine dioxygenase TET2 - Isoform 3 of Methylcytosine dioxygenase TET2Sequence View
10 20 30 40 50 60
MEQDRTTHAE GTRLSPFLIA PPSPISHTEP LAVKLQNGSP LAERPHPEVN GDTKWQSSQS
70 80 90 100 110 120
CYGISHMKGS QSSHESPHED RGYSRCLQNG GIKRTVSEPS LSGLHPNKIL KLDQKAKGES
130 140 150 160 170 180
NIFEESQERN HGKSSRQPNV SGLSDNGEPV TSTTQESSGA DAFPTRNYNG VEIQVLNEQE
190 200 210 220 230 240
GEKGRSVTLL KNKIVLMPNG ATVSAHSEEN TRGELLEKTQ CYPDCVSIAV QSTASHVNTP
250 260 270 280 290 300
SSQAAIELSH EIPQPSLTSA QINFSQTSSL QLPPEPAAMV TKACDADNAS KPAIVPGTCP
310 320 330 340 350 360
FQKAEHQQKS ALDIGPSRAE NKTIQGSMEL FAEEYYPSSD RNLQASHGSS EQYSKQKETN
370 380 390 400 410 420
GAYFRQSSKF PKDSISPTTV TPPSQSLLAP RLVLQPPLEG KGALNDVALE EHHDYPNRSN
430 440 450 460 470 480
RTLLREGKID HQPKTSSSQS LNPSVHTPNP PLMLPEQHQN DCGSPSPEKS RKMSEYLMYY
490 500 510 520 530 540
LPNHGHSGGL QEHSQYLMGH REQEIPKDAN GKQTQGSVQA APGWIELKAP NLHEALHQTK
550 560 570 580 590 600
RKDISLHSVL HSQTGPVNQM SSKQSTGNVN MPGGFQRLPY LQKTAQPEQK AQMYQVQVNQ
610 620 630 640 650 660
GPSPGMGDQH LQFQKALYQE CIPRTDPSSE AHPQAPSVPQ YHFQQRVNPS SDKHLSQQAT
670 680 690 700 710 720
ETQRLSGFLQ HTPQTQASQT PASQNSNFPQ ICQQQQQQQL QRKNKEQMPQ TFSHLQGSND
730 740 750 760 770 780
KQREGSCFGQ IKVEESFCVG NQYSKSSNFQ THNNTQGGLE QVQNINKNFP YSKILTPNSS
790 800 810 820 830 840
NLQILPSNDT HPACEREQAL HPVGSKTSNL QNMQYFPNNV TPNQDVHRCF QEQAQKPQQA
850 860 870 880 890 900
SSLQGLKDRS QGESPAPPAE AAQQRYLVHN EAKALPVPEQ GGSQTQTPPQ KDTQKHAALR
910 920 930 940 950 960
WLLLQKQEQQ QTQQSQPGHN QMLRPIKTEP VSKPSSYRYP LSPPQENMSS RIKQEISSPS
970 980 990 1000 1010 1020
RDNGQPKSII ETMEQHLKQF QLKSLCDYKA LTLKSQKHVK VPTDIQAAES ENHARAAEPQ
1030 1040 1050 1060 1070 1080
ATKSTDCSVL DDVSESDTPG EQSQNGKCEG CNPDKDEAPY YTHLGAGPDV AAIRTLMEER
1090 1100 1110 1120 1130 1140
YGEKGKAIRI EKVIYTGKEG KSSQGCPIAK WVYRRSSEEE KLLCLVRVRP NHTCETAVMV
1150 1160 1170 1180 1190 1200
IAIMLWDGIP KLLASELYSE LTDILGKCGI CTNRRCSQNE TRNCCCQGEN PETCGASFSF
1210 1220 1230 1240 1250 1260
GCSWSMYYNG CKFARSKKPR KFRLHGAEPK EEERLGSHLQ NLATVIAPIY KKLAPDAYNN
1270 1280 1290 1300 1310 1320
QVEFEHQAPD CCLGLKEGRP FSGVTACLDF SAHSHRDQQN MPNGSTVVVT LNREDNREVG
1330 1340 1350 1360 1370 1380
AKPEDEQFHV LPMYIIAPED EFGSTEGQEK KIRMGSIEVL QSFRRRRVIR IGELPKSCKK
1390 1400 1410 1420 1430 1440
KAEPKKAKTK KAARKRSSLE NCSSRTEKGK SSSHTKLMEN ASHMKQMTAQ PQLSGPVIRQ
1450 1460 1470 1480 1490 1500
PPTLQRHLQQ GQRPQQPQPP QPQPQTTPQP QPQPQHIMPG NSQSVGSHCS GSTSVYTRQP
1510 1520 1530 1540 1550 1560
TPHSPYPSSA HTSDIYGDTN HVNFYPTSSH ASGSYLNPSN YMNPYLGLLN QNNQYAPFPY
1570 1580 1590 1600 1610 1620
NGSVPVDNGS PFLGSYSPQA QSRDLHRYPN QDHLTNQNLP PIHTLHQQTF GDSPSKYLSY
1630 1640 1650 1660 1670 1680
GNQNMQRDAF TTNSTLKPNV HHLATFSPYP TPKMDSHFMG AASRSPYSHP HTDYKTSEHH
1690 1700 1710 1720 1730 1740
LPSHTIYSYT AAASGSSSSH AFHNKENDNI ANGLSRVLPG FNHDRTASAQ ELLYSLTGSS
1750 1760 1770 1780 1790 1800
QEKQPEVSGQ DAAAVQEIEY WSDSEHNFQD PCIGGVAIAP THGSILIECA KCEVHATTKV
1810 1820 1830 1840 1850 1860
NDPDRNHPTR ISLVLYRHKN LFLPKHCLAL WEAKMAEKAR KEEECGKNGS DHVSQKNHGK
1870 1880 1890 1900 1910
QEKREPTGPQ EPSYLRFIQS LAENTGSVTT DSTVTTSPYA FTQVTGPYNT FV
10 20 30 40 50 60
MEQDRTTHAE GTRLSPFLIA PPSPISHTEP LAVKLQNGSP LAERPHPEVN GDTKWQSSQS
70 80 90 100 110 120
CYGISHMKGS QSSHESPHED RGYSRCLQNG GIKRTVSEPS LSGLHPNKIL KLDQKAKGES
130 140 150 160 170 180
NIFEESQERN HGKSSRQPNV SGLSDNGEPV TSTTQESSGA DAFPTRNYNG VEIQVLNEQE
190 200 210 220 230 240
GEKGRSVTLL KNKIVLMPNG ATVSAHSEEN TRGELLEKTQ CYPDCVSIAV QSTASHVNTP
250 260 270 280 290 300
SSQAAIELSH EIPQPSLTSA QINFSQTSSL QLPPEPAAMV TKACDADNAS KPAIVPGTCP
310 320 330 340 350 360
FQKAEHQQKS ALDIGPSRAE NKTIQGSMEL FAEEYYPSSD RNLQASHGSS EQYSKQKETN
370 380 390 400 410 420
GAYFRQSSKF PKDSISPTTV TPPSQSLLAP RLVLQPPLEG KGALNDVALE EHHDYPNRSN
430 440 450 460 470 480
RTLLREGKID HQPKTSSSQS LNPSVHTPNP PLMLPEQHQN DCGSPSPEKS RKMSEYLMYY
490 500 510 520 530 540
LPNHGHSGGL QEHSQYLMGH REQEIPKDAN GKQTQGSVQA APGWIELKAP NLHEALHQTK
550 560 570 580 590 600
RKDISLHSVL HSQTGPVNQM SSKQSTGNVN MPGGFQRLPY LQKTAQPEQK AQMYQVQVNQ
610 620 630 640 650 660
GPSPGMGDQH LQFQKALYQE CIPRTDPSSE AHPQAPSVPQ YHFQQRVNPS SDKHLSQQAT
670 680 690 700 710 720
ETQRLSGFLQ HTPQTQASQT PASQNSNFPQ ICQQQQQQQL QRKNKEQMPQ TFSHLQGSND
730 740 750 760 770 780
KQREGSCFGQ IKVEESFCVG NQYSKSSNFQ THNNTQGGLE QVQNINKNFP YSKILTPNSS
790 800 810 820 830 840
NLQILPSNDT HPACEREQAL HPVGSKTSNL QNMQYFPNNV TPNQDVHRCF QEQAQKPQQA
850 860 870 880 890 900
SSLQGLKDRS QGESPAPPAE AAQQRYLVHN EAKALPVPEQ GGSQTQTPPQ KDTQKHAALR
910 920 930 940 950 960
WLLLQKQEQQ QTQQSQPGHN QMLRPIKTEP VSKPSSYRYP LSPPQENMSS RIKQEISSPS
970 980 990 1000 1010 1020
RDNGQPKSII ETMEQHLKQF QLKSLCDYKA LTLKSQKHVK VPTDIQAAES ENHARAAEPQ
1030 1040 1050 1060 1070 1080
ATKSTDCSVL DDVSESDTPG EQSQNGKCEG CNPDKDEAPY YTHLGAGPDV AAIRTLMEER
1090 1100 1110 1120 1130 1140
YGEKGKAIRI EKVIYTGKEG KSSQGCPIAK WVYRRSSEEE KLLCLVRVRP NHTCETAVMV
1150 1160 1170 1180 1190 1200
IAIMLWDGIP KLLASELYSE LTDILGKCGI CTNRRCSQNE TRNCCCQGEN PETCGASFSF
1210 1220 1230 1240 1250 1260
GCSWSMYYNG CKFARSKKPR KFRLHGAEPK EEERLGSHLQ NLATVIAPIY KKLAPDAYNN
1270 1280 1290 1300 1310 1320
QVEFEHQAPD CCLGLKEGRP FSGVTACLDF SAHSHRDQQN MPNGSTVVVT LNREDNREVG
1330 1340 1350 1360 1370 1380
AKPEDEQFHV LPMYIIAPED EFGSTEGQEK KIRMGSIEVL QSFRRRRVIR IGELPKSCKK
1390 1400 1410 1420 1430 1440
KAEPKKAKTK KAARKRSSLE NCSSRTEKGK SSSHTKLMEN ASHMKQMTAQ PQLSGPVIRQ
1450 1460 1470 1480 1490 1500
PPTLQRHLQQ GQRPQQPQPP QPQPQTTPQP QPQPQHIMPG NSQSVGSHCS GSTSVYTRQP
1510 1520 1530 1540 1550 1560
TPHSPYPSSA HTSDIYGDTN HVNFYPTSSH ASGSYLNPSN YMNPYLGLLN QNNQYAPFPY
1570 1580 1590 1600 1610 1620
NGSVPVDNGS PFLGSYSPQA QSRDLHRYPN QDHLTNQNLP PIHTLHQQTF GDSPSKYLSY
1630 1640 1650 1660 1670 1680
GNQNMQRDAF TTNSTLKPNV HHLATFSPYP TPKMDSHFMG AASRSPYSHP HTDYKTSEHH
1690 1700 1710 1720 1730 1740
LPSHTIYSYT AAASGSSSSH AFHNKENDNI ANGLSRVLPG FNHDRTASAQ ELLYSLTGSS
1750 1760 1770 1780 1790 1800
QEKQPEVSGQ DAAAVQEIEY WSDSEHNFQD PCIGGVAIAP THGSILIECA KCEVHATTKV
1810 1820 1830 1840 1850 1860
NDPDRNHPTR ISLVLYRHKN LFLPKHCLAL WEAKMAEKAR KEEECGKNGS DHVSQKNHGK
1870 1880 1890 1900 1910
QEKREPTGPQ EPSYLRFIQS LAENTGSVTT DSTVTTSPYA FTQVTGPYNT FV
Protein Neighborhood
Domains & Features
3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q4JK59-1-unknown | MEQDRT... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q4JK59-1301-unknown | MPNGST... | 1301 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt91902 | |||
| Q4JK59-1301-unknown | MPNGST... | 1301 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q4JK59-1301-unknown | MPNGST... | 1301 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| Q4JK59-1333-unknown | MYIIAP... | 1333 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt91903 | |||
| Q4JK59-1333-unknown | MYIIAP... | 1333 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110002 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...YNTFV | 1912 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...YNTFV | 1912 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87521 | |||
| ...YNTFV | 1912 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87520 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|